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Malmanche N, Dourlen P, Gistelinck M, Demiautte F, Link N, Dupont C, Vanden Broeck L, Werkmeister E, Amouyel P, Bongiovanni A, Bauderlique H, Moechars D, Royou A, Bellen HJ, Lafont F, Callaerts P, Lambert JC, Dermaut B (2017) Developmental expression of 4-repeat-Tau induces neuronal aneuploidy in Drosophila tauopathy models. Scientific Reports 7:40764. [Abstract]

Chao HT, Davids M, Burke E, Pappas JG, Rosenfeld JA, McCarty AJ, Davis T, Wolfe L, Toro C, Tifft C, Xia F, Stong N, Johnson TK, Warr CG, Undiagnosed Diseases Network, Yamamoto S, Adams DR, Markello TC, Gahl WA, Bellen HJ, Wangler MF, Malicdan MC (2017) A syndromic neurodevelopmental disorder caused by de novo variants in EBF3. American Journal of Human Genetics 100:128-137. [Abstract]

Lin G, Mao D, Bellen HJ (2017) Amyotrophic Lateral Sclerosis pathogenesis converges on defects in protein homeostasis associated with TDP-43 mislocalization and proteasome-mediated degradation overload. Current Topics in Developmental Biology 121:111-171. [Abstract]

Yoon WH, Sandoval H, Nagarkar-Jaiswal S, Jaiswal M, Yamamoto S, Haelterman NA, Putluri N, Putluri V, Sreekumar A, Tos T, Aksoy A, Donti T, Graham BH, Ohno M, Nishi E, Hunter J, Muzny DM, Carmichael J, Shen J, Arboleda VA, Nelson SF, Wangler MF, Karaca E, Lupski JR, Bellen HJ (2017) Loss of Nardilysin, a mitochondrial co-chaperone for α-Ketoglutarate Dehydrogenase, promotes mTORC1 activation and neurodegeneration. Neuron 93:115-131. [Abstract]



Chen K, Ho TS, Lin G, Tan KL, Rasband MN, Bellen HJ (2016) Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals. eLife 5:e20732. [Abstract]

Jakobsdottir J, van der Lee SJ, Bis JC, Chouraki V, Li-Kroeger D, Yamamoto S, Grove ML, Naj A, Vronskaya M, Salazar JL, DeStefano AL, Brody JA, Smith AV, Amin N, Sims R, Ibrahim-Verbaas CA, Choi SH, Satizabal CL, Lopez OL, Beiser A, Ikram MA, Garcia ME, Hayward C, Varga TV, Ripatti S, Franks PW, Hallmans G, Rolandsson O, Jansson JH, Porteous DJ, Salomaa V, Eiriksdottir G, Rice KM, Bellen HJ, Levy D, Uitterlinden AG, Emilsson V, Rotter JI, Aspelund T, Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, Alzheimer's Disease Genetic Consortium, Genetic and Environmental Risk in Alzheimer's Disease consortium, O'Donnell CJ, Fitzpatrick AL, Launer LJ, Hofman A, Wang LS, Williams J, Schellenberg GD, Boerwinkle E, Psaty BM, Seshadri S, Shulman JM, Gudnason V, van Duijn CM (2016) Rare functional variant in TM2D3 is associated with late-onset Alzheimer's disease. PLoS Genetics 12:e1006327. [Abstract]

Harel T, Yoon WH, Garone C, Gu S, Coban-Akdemir Z, Eldomery MK, Posey JE, Jhangiani SN, Rosenfeld JA, Cho MT, Fox S, Withers M, Brooks SM, Chiang T, Duraine L, Erdin S, Yuan B, Shao Y, Moussallem E, Lamperti C, Donati MA, Smith JD, McLaughlin HM, Eng CM, Walkiewicz M, Xia F, Pippucci T, Magini P, Seri M, Zeviani M, Hirano M, Hunter JV, Srour M, Zanigni S, Lewis RA, Muzny DM, Lotze TE, Boerwinkle E, Baylor-Hopkins Center for Mendelian Genomics, University of Washington Center for Mendelian Genomics, Gibbs RA, Hickey SE, Graham BH, Yang Y, Buhas D, Martin DM, Potocki L, Graziano C, Bellen HJ, Lupski JR (2016) Recurrent de novo and biallelic variation of ATAD3A, encoding a mitochondrial membrane protein, results in distinct neurological syndromes. American Journal of Human Genetics 99:831-845. [Abstract]

Chen K, Lin G, Haelterman NA, Ho TS, Li T, Li Z, Duraine L, Graham BH, Jaiswal M, Yamamoto S, Rasband MN, Bellen HJ (2016) Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. eLife 5:e16043. [Abstract]

Chouhan AK, Guo C, Hsieh YC, Ye H, Senturk M, Zuo Z, Li Y, Chatterjee S, Botas J, Jackson GR, Bellen HJ, Shulman JM (2016) Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease. Acta Neuropathologica Communications 4:62. [Abstract]

Li T, Giagtzoglou N, Eberl D, Nagarkar-Jaiswal S, Cai T, Godt D, Groves AK, Bellen HJ (2016) The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals. eLife 5:e15258. [Abstract]

Ali YO, Allen HM, Yu L, Li-Kroeger D, Bakhshizadehmahmoudi D, Hatcher A, McCabe C, Xu J, Bjorklund N, Taglialatela G, Bennett DA, De Jager PL, Shulman JM, Bellen HJ, Lu HC (2016) NMNAT2:HSP90 complex mediates proteostasis in proteinopathies. PLoS Biology 14:e1002472. [Abstract]

Li T, Fan J, Blanco-Sánchez B, Giagtzoglou N, Lin G, Yamamoto S, Jaiswal M, Chen K, Zhang J, Wei W, Lewis MT, Groves AK, Westerfield M, Jia J, Bellen HJ (2016) Ubr3, a novel modulator of Hh signaling affects the degradation of Costal-2 and Kif7 through poly-ubiquitination. PLoS Genetics 12:e1006054. [Abstract]

Chao YH, Robak LA, Xia F, Koenig MK, Adesina A, Bacino CA, Scaglia F, Bellen HJ, Wangler MF (2016) Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila. Human Molecular Genetics 25:1846-1856. [Abstract]

Ugur B, Chen K, Bellen HJ (2016) Drosophila tools and assays for the study of human diseases. Disease Models & Mechanisms 9:235-244. [Abstract]

David-Morrison G, Xu Z, Rui YN, Charng WL, Jaiswal M, Yamamoto S, Xiong B, Zhang K, Sandoval H, Duraine L, Zuo Z, Zhang S, Bellen HJ (2016) WAC regulates mTOR activity by by acting as an adaptor for the TTT and Pontin/Reptin complexes. Developmental Cell 36:139-151. [Abstract]



Tan L, Zhang KX, Pecot MY, Nagarkar-Jaiswal S, Lee PT, Takemura SY, McEwen JM, Nern A, Xu S, Tadros W, Chen Z, Zinn K, Bellen HJ, Morey M, Zipursky SL (2015) Ig superfamily ligand and receptor pairs expressed in synaptic partners in Drosophila. Cell 163:1756-1769. [Abstract] [Faculty of 1000]

Carrillo RA, Özkan E, Menon KP, Nagarkar-Jaiswal S, Lee PT, Jeon M, Birnbaum ME, Bellen HJ, Garcia KC, Zinn K (2015) Control of synaptic connectivity by a network of Drosophila IgSF cell surface proteins. Cell 163:1770-1782. [Abstract] [Faculty of 1000]

Bellen HJ, Yamamoto S (2015) Morgan's legacy: fruit flies and the functional annotation of conserved genes. Cell 163:12-14. [Abstract]

Wu SP, Kao CY, Wang L, Creighton CJ, Yang J, Donti TR, Harmancey R, Vasquez HG, Graham BH, Bellen HJ, Taegtmeyer H, Chang CP, Tsai MJ, Tsai SY (2015) Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nature Communications 6:8245. [Abstract]

Zanet J, Benrabah E, Li T, Pélissier-Monier A, Chanut-Delalande H, Ronsin B, Bellen HJ, Payre F, Plaza S (2015) Pri sORF peptides induce selective proteasome-mediated protein processing. Science 349:1356-1358. [Abstract] [Faculty of 1000]

Wang F, Jiang L, Chen Y, Haelterman NA, Bellen HJ, Chen R (2015) FlyVar: a database for genetic variation in Drosophila melanogaster. Database 2015:bav079. [Abstract]

Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J (2015) Safeguarding gene drive experiments in the laboratory. Science 349:927-929. [Abstract]

Wang S, Bellen HJ (2015) The retromer complex in development and disease. Development 42: 2392-2396. [Abstract]

Jaiswal M, Haelterman NA, Sandoval H, Xiong B, Donti T, Kalsotra A, Yamamoto S, Cooper TA, Graham BH, Bellen HJ (2015) Impaired mitochondrial energy production causes light induced photoreceptor degeneration independent of oxidative stress. PLoS Biology 13: e100219. [Article]

Nagarkar-Jaiswal S, DeLuca SZ, Lee PT, Lin WW, Pan H, Zuo Z, Lv J, Spradling AC, Bellen HJ (2015) A genetic toolkit for tagging intronic MiMIC containing genes. eLife 4:e08469. [Article]

Nagarkar-Jaiswal S, Lee PT, Campbell ME, Chen K, Anguiano-Zarate S, Cantu Gutierrez M, Busby T, Lin WW, He Y, Schulze KL, Booth BW, Evans-Holm M, Venken KJ, Levis RW, Spradling AC, Hoskins RA, Bellen HJ (2015) A library of MiMICs allows tagging of genes and reversible spatial and temporal knockdown of proteins in Drosophila. eLife 4:e05338. [Article]

Tian X, Gala U, Zhang Y, Shang W, Nagarkar Jaiswal S, di Ronza A, Jaiswal M, Yamamoto S, Sandoval H, Duraine L, Sardiello M, Sillitoe RV, Venkatachalam K, Fan H, Bellen HJ, Tong C (2015) A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biology 13:e1002103. [Article] [Faculty of 1000]

Rui YN, Xu Z, Patel B, Chen Z, Chen D, Tito A, David G, Sun Y, Stimming EF, Bellen HJ, Cuervo AM, Zhang S (2015) Huntingtin functions as a scaffold for selective macroautophagy. Nature Cell Biology 17:262-275. [Abstract]

Wangler MF, Yamamoto S, Bellen HJ (2015) Fruit flies in biomedical research. Genetics 199:639-653. [Abstract] [Faculty of 1000]

Liu L, Zhang K, Sandoval H, Yamamoto S, Jaiswal M, Sanz E, Li Z, Hui J, Graham BH, Quintana A, Bellen HJ (2015) Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Cell 160:177-190. [Abstract]



Wong CO, Chen K, Lin YQ, Chao Y, Duraine L, Lu Z, Yoon WH, Sullivan JM, Broadhead GT, Sumner CJ, Lloyd TE, Macleod GT, Bellen HJ, Venkatachalam K (2014) A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission. Neuron 84:764-777. [Abstract]

Sandoval H, Yao CK, Chen K, Jaiswal M, Donti T, Lin YQ, Bayat V, Xiong B, Zhang K, David G, Charng WL, Yamamoto S, Duraine L, Graham BH, Bellen HJ (2014) Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production. eLife 3:e03558. [Article]

Bellen HJ (2014) Survival of the fittest tools. Genetics 198:427-428. [Article]

Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S, Vissers LE, de Ligt J, Jhangiani SN, Xie Y, Tsang SH, Parman Y, Sivaci M, Battaloglu E, Muzny D, Wan YW, Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Link N, Schulze KL, Boerwinkle E, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler MF, Bellen HJ (2014) A Drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell 159:200-214. [Abstract] [Faculty of 1000]

Haelterman NA, Jiang L, Li Y, Bayat V, Sandoval H, Ugur B, Tan KL, Zhang K, Bei D, Xiong B, Charng WL, Busby T, Jawaid A, David G, Jaiswal M, Venken KJ, Yamamoto S, Chen R, Bellen HJ (2014) Large-scale identification of chemically induced mutations in Drosophila melanogaster. Genome Research 24:1707-1718. [Article]

Halstead JM, Lin YQ, Duraine L, Hamilton RS, Ball G, Neely GG, Bellen HJ, Davis I (2014) Syncrip/hnRNP Q influences synaptic transmission and regulates BMP signaling at the Drosophila neuromuscular synapse. Biology Open 3:839-849. [Article]

Yamamoto S, Schulze KL, Bellen HJ (2014) Introduction to Notch signaling. Methods in Molecular Biology 1187:1-14. [Abstract]

Haelterman NA, Yoon WH, Sandoval H, Jaiswal M, Shulman JM, Bellen HJ (2014) A mitocentric view of Parkinson's Disease. Annual Review of Neuroscience 37:137-159. [Abstract]

Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ (2014) The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biology 12:e1001847. [Article]

Charng WL, Yamamoto S, Bellen HJ (2014) Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases. Current Opinion in Neurobiology 27C:158-164. [Abstract]

Venken KJT, Bellen HJ (2014) Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster. Methods 68:15-28. [Abstract]

Moustaqim-Barrette A, Lin YQ, Pradhan S, Neely GG, Bellen HJ, Tsuda H (2014) The Amyotrophic Lateral Sclerosis 8 protein, VAP, is required for ER protein quality control. Human Molecular Genetics 23:1975-1989. [Abstract]

Charng WL, Yamamoto S, Jaiswal M, Bayat V, Xiong B, Zhang K, Sandoval H, David G, Gibbs S, Lu HC, Chen K, Giagtzoglou N, Bellen HJ (2014) Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates Notch signaling via Rab1 and Rab11. PLoS Biology 12:e1001777. [Article]



Cassidy JJ, Jha AR, Posadas DM, Giri R, Venken KJ, Ji J, Jiang H, Bellen HJ, White KP, Carthew RW (2013) miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. Cell 155:1556-1567. [Abstract]

Han SM, El Oussini H, Scekic-Zahirovic J, Vibbert J, Cottee P, Prasain JK, Bellen HJ, Dupuis L, Miller MA (2013) VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in Caenorhabditis elegans. PLoS Genetics 9:e1003738. [Abstract]

Xiong B, Bellen HJ (2013) Rhodopsin homeostasis and retinal degeneration: lessons from the fly. Trends in Neurosciences 36:652-660. [Abstract]

Ali YO, Li-Kroeger D, Bellen HJ, Zhai RG, Lu HC (2013) NMNATs, evolutionarily conserved neuronal maintenance factors. Trends in Neurosciences 36:632-640. [Abstract]

Yamamoto S, Bayat V, Bellen HJ, Tan C (2013) Protein phosphatase 1β limits ring canal constriction during Drosophila germline cyst formation. PLoS One 8:e70502. [Abstract]

Giagtzoglou N, Li T, Yamamoto S, Bellen HJ (2013) Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition. Journal of Cell Science 126:3686-3696. [Abstract]

Zhang K, Li Z, Jaiswal M, Bayat V, Xiong B, Sandoval H, Charng W-L, David G, Haueter C, Yamamoto S, Graham BH, Bellen HJ (2013) The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit. Journal of Cell Biology 200:807-820. [Abstract]

Winther AM, Jiao W, Vorontsova O, Rees KA, Koh TW, Sopova E, Schulze KL, Bellen HJ, Shupliakov O (2013) The dynamin-binding domains of Dap160/Intersectin affect bulk membrane retrieval in synapses. Journal of Cell Science 126:1021-1031. [Abstract]



Xiong B, Bayat V, Jaiswal M, Zhang K, Sandoval H, Charng W-L, Li TC, David G, Duraine L, Lin YQ, Neely GG, Yamamoto S, Bellen HJ (2012) Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells. PLoS Biology 10:e1001438. [Article]

Yamamoto S, Charng W-L, Rana NA, Kakuda S, Jaiswal M, Bayat V, Xiong B, Zhang K, Sandoval H, David G, Wang H, Haltiwanger RS, Bellen HJ (2012) A mutation in EGF repeat 8 of Notch discriminates between Serrate/Jagged and Delta family ligands. Science 338:1229-1232. [Abstract | PDF | Editor's Choice | Faculty of 1000]

Chen YC, Lin YQ, Banerjee S, Venken K, Li J, Ismat A, Chen K, Duraine L, Bellen HJ, Bhat MA (2012) Drosophila Neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission. Journal of Neuroscience 32:16018-16030. [Abstract]

Jaiswal M, Sandoval H, Zhang K, Bayat V, Bellen HJ (2012) Probing mechanisms that underlie human neurodegenerative disease in Drosophila. Annual Review of Genetics 46:371-396. [Abstract]

Szabad J, Bellen HJ, Venken KJT (2012) An assay to detect in vivo Y chromosome loss in Drosophila wing disc cells. G3 2:1095-1102. [Abstract]

Alves-Silva J, Sánchez-Soriano N, Beaven R, Klein M, Parkin J, Millard TH, Bellen HJ, Venken KJ, Ballestrem C, Kammerer RA, Prokop A (2012) Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins). Journal of Neuroscience 32:9143-9158. [Abstract]

Bayat V, Thiffault I, Jaiswal M, Tétreault M, Donti T, Sasarman F, Bernard G, Demers-Lamarche J, Dicaire M, Mathieu V, Rioux M, Lesage J, Lourenco CM, Li Z, Haueter C, Shoubridge E, Graham BH, Brais B, Bellen HJ (2012) Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. PLoS Biology 10:e1001288. [Abstract]

Venken KJ, Bellen HJ (2012) Genome-wide manipulations of Drosophila melanogaster with transposons, Flp recombinase, and ΦC31 integrase. Methods in Molecular Biology 859:203-228. [Abstract]

Han SM, Tsuda H, Yang Y, Vibbert J, Cottee P, Lee SJ, Winek J, Haueter C, Bellen HJ, Miller MA (2012) Secreted VAPB/ALS8 Major Sperm Protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors. Developmental Cell 22:348-362. [Abstract] [Faculty of 1000]

Giagtzoglou N, Yamamoto S, Zitserman D, Graves HK, Schulze KL, Wang H, Klein H, Rogiers F, Bellen HJ (2012) dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions. Journal of Cell Biology 196:65-83. [Abstract]

Neumüller RA, Wirtz-Peitz F, Lee S, Kwon Y, Buckner M, Hoskins RA, Venken KJ, Bellen HJ, Mohr E, Perrimon N (2012) Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. Genetics 190:931-940. [Abstract]



Xue M, Giagtzoglou N, Bellen HJ (2011) Dueling Ca2+ sensors in neurotransmitter release. Cell 147:491-493. [Abstract]

Venken KJT, Simpson JH, Bellen HJ (2011) Genetic manipulation of genes and cells in the nervous system of the fruit fly. Neuron 72:202-230. [Abstract]

Spradling AC, Bellen HJ, Hoskins RA (2011) Drosophila P elements preferentially transpose to replication origins. Proceedings of the National Academy of Sciences USA 108:15948-15953. [Abstract]

Mitne-Neto M, Machado-Costa M, Marchetto MC, Bengtson MH, Joazeiro CA, Tsuda H, Bellen HJ, Silva HA, Oliveira AS, Lazar M, Muotri AR, Zatz M (2011) Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients. Human Molecular Genetics 20:3642-3652. [Abstract]

Tong C, Ohyama T, Tien A, Rajan A, Haueter CM, Bellen HJ (2011) rich regulates target specificity of photoreceptor cells and N-Cadherin trafficking in the Drosophila visual system via Rab6. Neuron 71:447-459. [Abstract]

Bellen HJ, Levis RW, He Y, Carlson JW, Evans-Holm M, Bae E, Kim J, Metaxakis A, Savakis C, Schulze KL, Hoskins RA, Spradling AC (2011) The Drosophila Gene Disruption Project: progress using transposons with distinctive site-specificities. Genetics 188:731-743. [Abstract]

Nègre N, Brown CD, Ma L, Bristow CA, Miller SW, Wagner U, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony RF, Chen J, Hwang L, Cheng C, Auburn RP, Davis MB, Domanus M, Shah PK, Morrison CA, Zieba J, Suchy S, Senderowicz L, Victorsen A, Bild NA, Grundstad AJ, Hanley D, MacAlpine DM, Mannervik M, Venken K, Bellen H, White R, Gerstein M, Russell S, Grossman RL, Ren B, Posakony JW, Kellis M, White KP (2011) A cis-regulatory map of the Drosophila genome. Nature 471:527-531. [Abstract] [Faculty of 1000]

Bayat V, Jaiswal M, Bellen HJ (2011) The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases. Current Opinion in Neurobiology 21:182-188. [Abstract]

Venken KJT, Schulze KL, Haelterman NA, Pan H, He Y, Evans-Holm M, Carlson JW, Levis RW, Spradling AC, Hoskins RA, Bellen HJ (2011) MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Nature Methods 8:737-743. [Abstract]

Zheng L, Michelson Y, Freger V, Avraham Z, Venken KJT, Bellen HJ, Justice MJ, Wides R (2011) Drosophila Ten-m and Filamin affect motor neuron growth cone guidance. PLoS One 6:e22956. [Abstract]



modENCODE Consortium (2010) Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science 330:1787-1797. [Abstract]

Neely GG, Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai F, Smith SB, Diatchenko L, Gupta V, Xia CP, Amann S, Kreitz S, Heindl-Erdmann C, Wolz S, Ly CV, Arora S, Sarangi R, Dan D, Novatchkova M, Rosenzweig M, Gibson DG, Truong D, Schramek D, Zoranovic T, Cronin SJ, Angjeli B, Brune K, Dietzl G, Maixner W, Meixner A, Thomas W, Pospisilik JA, Alenius M, Kress M, Subramaniam S, Garrity PA, Bellen HJ, Woolf CJ, Penninger JM (2010) A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell 143:628-638. [Abstract]

Venken KJ, Popodi E, Holtzman SL, Schulze KL, Park S, Carlson JW, Hoskins RA, Bellen HJ, Kaufman TC (2010) A molecularly defined duplication set for the X chromosome of Drosophila melanogaster. Genetics 186:1111-1125. [Abstract]

Yamamoto S, Charng WL, Bellen HJ (2010) Endocytosis and intracellular trafficking of Notch and its ligands. Current Topics in Developmental Biology 92:165-200. [Abstract] [PDF (SAMPLE)]

Bellen HJ, Tong C, Tsuda H (2010) 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future. Nature Reviews Neuroscience 11:514-522. [Abstract] [PDF]



Giagtzoglou N, Mahoney T, Yao CK, Bellen HJ (2009) Rab3 GTPase lands Bruchpilot. Neuron 64:595-597. [Abstract]

Xue M, Lin YQ, Pan H, Reim K, Deng H, Bellen HJ, Rosenmund C (2009) Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron 64:367-380. [Abstract] [Faculty of 1000]

Giagtzoglou N, Ly CV, Bellen HJ (2009) Cell adhesion, the backbone of the synapse: "vertebrate" and "invertebrate" perspectives. Cold Spring Harbor Perspectives in Biology 1:a003079. [Abstract]

Yao CK, Lin YQ, Ly CV, Ohyama T, Haueter C, Moiseenkova-Bell VY, Wensel TG, Bellen HJ (2009) A synaptic vesicle- and presynaptic membrane-associated ion channel regulates resting Ca2+ levels and synaptic endocytosis. Cell 138:947-960. [Abstract] [Faculty of 1000]

Fotowat H, Fayyazuddin A, Bellen HJ, Gabbiani F (2009) A novel neuronal pathway for visually guided escape in Drosophila melanogaster. Journal of Neurophysiology 102:875-885. [Abstract] [Faculty of 1000]

Verstreken P, Ohyama T, Haueter C, Habets RL, Lin YQ, Swan LE, Ly CV, Venken KJ, De Camilli P, Bellen HJ (2009) Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling. Neuron 63:203-215. [Abstract] [Faculty of 1000]

Giagtzoglou N, Xue M, Bellen HJ (2009) An old dog learns a new trick: Synaptotagmin, a Ca2+ sensor for spontaneous release at central synapses. Cell Science Reviews 6(2). [PDF]

Rajan A, Tien AC, Haueter CM, Schulze KL, Bellen HJ (2009) The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nature Cell Biology 11:815-824. [Abstract] [Faculty of 1000]

Patel PH, Costa-Mattioli M, Schulze KL, Bellen HJ (2009) The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. Journal of Cell Biology 185:1181-1194. [Abstract]

Andrews HK, Giagtzoglou N, Yamamoto S, Schulze KL, Bellen HJ (2009) Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila. EMBO Reports 10:636-641. [Abstract]

Venken KJT, Carlson JW, Schulze KL, Pan H, He Y, Spokony R, Wan KH, Koriabine M, de Jong PJ, White KP, Bellen HJ, Hoskins RA (2009) Versatile P[acman] BAC Libraries for transgenesis studies in Drosophila melanogaster. Nature Methods 6:431-434. [Abstract] [Faculty of 1000]

Giagtzoglou N, Lin YQ, Haueter C, Bellen HJ (2009) Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction. Journal of Neuroscience 29:5628-5639. [Abstract]

Tien AC, Rajan A, Bellen HJ (2009) A Notch updated. Journal of Cell Biology 184:621-629. [Abstract]



Tien AC, Rajan A, Schulze KL, Ryoo HD, Acar M, Steller H, Bellen HJ (2008) Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster. Journal of Cell Biology 182:1113-1125. [Abstract]

Tsuda H, Han SM, Yang Y, Tong C, Lin YQ, Mohan K, Haueter C, Zoghbi A, Harati Y, Kwan J, Miller MA, Bellen HJ (2008) The Amyotrophic Lateral Sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell 133:963-977. [Abstract] [Faculty of 1000]

Zhai RG, Zhang F, Hiesinger PR, Cao Y, Haueter CM, Bellen HJ (2008) NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration. Nature 452:887-991. [Abstract] [Faculty of 1000]

Ly CV, Yao CK, Verstreken P, Ohyama T, Bellen HJ (2008) straightjacket is required for the synaptic stabilization of cacophony, a voltage gated calcium channel α1 subunit. Journal of Cell Biology 181:157-170. [Abstract]

Acar M, Jafar-Nejad H, Takeuchi H, Rajan A, Ibrani D, Rana NA, Pan H, Haltiwanger RS, Bellen HJ (2008) Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell 132:247-258. [Article] [Faculty of 1000]

Romero E, Cha GH, Verstreken P, Ly CV, Hughes RE, Bellen HJ, Botas J (2008) Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm. Neuron 57:27-40. [Abstract] [Faculty of 1000]

Zhang W, Wang D, Volk E, Bellen HJ, Hiesinger PR, Quiocho FA (2008) V-ATPase V0 sector subunit a1 in neurons is a target of calmodulin. Journal of Biological Chemistry 283:294-300. [Abstract]

Verstreken P, Ohyama T, Bellen HJ (2008) FM 1-43 labeling of synaptic vesicle pools at the Drosophila neuromuscular junction. Methods in Molecular Biology 440:349-369. [Abstract]



Ohyama T, Verstreken P, Ly CV, Rosenmund T, Rajan A, Tien AC, Haueter C, Schulze KL, Bellen HJ (2007) Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles. Journal of Cell Biology 179:1481-1496. [Article]

Venken KJT, Bellen HJ (2007) Transgenesis uprgrades for Drosophila melanogaster. Development 134:3571-3584. [Abstract]

Koh TW, Korolchuk VI, Wairkar YP, Jiao W, Evergren E, Pan H, Zhou Y, Venken KJT, Shupliakov O, Robinson IM, O'Kane CJ, Bellen HJ (2007) Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development. Journal of Cell Biology 178:309-322. [Article] [Faculty of 1000]

Zhang J, Schulze KL, Hiesinger PR, Suyama K, Wang S, Fish M, Acar M, Hoskins RA, Bellen HJ, Scott MP (2007) Thirty-one flavors of Drosophila Rab proteins. Genetics 176:1307-1322. [Article] [Stocks]



Venken KJT, He Y, Hoskins RA, Bellen HJ (2006) P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science 314:1747-1751. [Abstract] [Faculty of 1000]

Zhai RG, Cao Y, Hiesinger PR, Zhou Y, Mehta SQ, Schulze KL, Verstreken P, Bellen HJ (2006) Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. PLoS Biology 4:e416. [Article]

Hiesinger PR, Zhai RG, Zhou Y, Koh TW, Mehta SQ, Schulze KL, Cao Y, Verstreken P, Clandinin TR, Fischbach KF, Meinertzhagen IA, Bellen HJ (2006) Activity-independent prespecification of synaptic partners in the visual map of Drosophila. Current Biology 16:1835-1843. [Abstract] [Faculty of 1000]

Acar M, Jafar-Nejad H, Giagtzoglou N, Yallampalli S, David G, He Y, Delidakis C, Bellen HJ (2006) Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. Development 133:1979-1989. [Abstract] [Faculty of 1000]

Jafar-Nejad H, Tien AC, Acar M, Bellen HJ (2006) Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development 133:1683-1692. [Abstract]

Seto ES, Bellen HJ (2006) Internalization is required for proper wingless signaling in Drosophila. Journal of Cell Biology 173:95-106. [Article] [Faculty of 1000]

Fayyazuddin A, Zaheer MA, Hiesinger PR, Bellen HJ (2006) The nicotinic acetylcholine receptor Dα7 is required for an escape behavior in Drosophila. PLoS Biology 4:e63. [Article]

Giagtzoglou N, Bellen HJ (2006) Fighting anthrax with flies. Proceedings of the National Academy of Sciences USA 103:3013-3014. [Article]



Shroyer NF, Wallis D, Venken KJT, Bellen HJ, Zoghbi HY (2005) Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes and Development 19:2412-2417. [Article]

Wu S, Mehta SQ, Pichaud F, Bellen HJ, Quiocho FA (2005) Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo. Nature Structural and Molecular Biology 12:879-885. [Abstract]

Jafar-Nejad H, Andrews HK, Acar M, Bayat V, Wirtz-Peitz F, Mehta SQ, Knoblich JA, Bellen HJ (2005) Sec15, a component of the exocyst, promotes Notch signaling during the asymmetric division of Drosophila sensory organ precursors. Developmental Cell 9:351-363. [Abstract]

Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJ, Botas J, Orr HT, Bellen HJ, Zoghbi HY (2005) The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell 122:633-644. [Abstract]

Verstreken P, Ly CV, Venken KJ, Koh TW, Zhou Y, Bellen HJ (2005) Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron 47:365-378. [Abstract] [Faculty of 1000]

Dermaut B, Norga KK, Kania A, Verstreken P, Pan H, Zhou Y, Callaerts P, Bellen HJ (2005) Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer. Journal of Cell Biology 170:127-139. [Article]

Hiesinger PR, Fayyazuddin A, Mehta SQ, Rosenmund T, Schulze KL, Zhai RG, Verstreken P, Cao Y, Zhou Y, Kunz J, Bellen HJ (2005) The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell 121:607-620. [Abstract]

Mehta SQ, Hiesinger PR, Beronja S, Zhai RG, Schulze KL, Verstreken P, Cao Y, Zhou Y, Tepass U, Crair MC, Bellen HJ (2005) Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron 46:219-232. [Abstract]

Venken KJT, Bellen HJ (2005) Emerging technologies for gene manipulation in Drosophila melanogaster. Nature Reviews Genetics 6:167-178. [Abstract]

Escudero LM, Caminero E, Schulze KL, Bellen HJ, Modolell J (2005) Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila. Development 132:1211-1222. [Abstract]

Beckstead RB, Ner SS, Hales KG, Grigliatti TA, Baker BS, Bellen HJ (2005) Bonus, a Drosophila TIF1 homologue, is a chromatin associated protein that acts as a modifier of position effect variegation. Genetics 169:783-794. [Article]



Kazanjian A, Wallis D, Au N, Nigam R, Venken KJ, Cagle PT, Dickey BF, Bellen HJ, Gilks CB, Grimes HL (2004) Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells. Cancer Research 64:6874-6882. [Abstract]

Zhai RG, Bellen HJ (2004) Hauling t-SNAREs on the microtubule highway. Nature Cell Biology 6:918-919. [Abstract]

Jafar-Nejad H, Bellen HJ (2004) Gfi/Pag-3/senseless zinc finger proteins: a unifying theme? Molecular and Cellular Biology 24:8803-8812. [Article]

Zhai RG, Bellen HJ (2004) The architecture of the active zone in the presynaptic nerve terminal. Physiology 19:262-270. [Abstract]

Koh TW, Verstreken P, Bellen HJ (2004) Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis. Neuron 43:193-205. [Abstract]

Bellen HJ, Levis RW, Liao G, He Y, Carlson JW, Tsang G, Evans-Holm M, Hiesinger PR, Schulze KL, Rubin GM, Hoskins RA, Spradling AC (2004) The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics 167:761-781. [Article]

Pesah Y, Pham T, Burgess H, Middlebrooks B, Verstreken P, Zhou Y, Harding M, Bellen H, Mardon G (2004) Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development 131:2183-2194. [Abstract]

Hiesinger PR, Bellen HJ (2004) Flying in the face of total disruption. Nature Genetics 36:211-212. [Abstract]

Seto ES, Bellen HJ (2004) The ins and outs of Wingless signaling. Trends in Cell Biology 14:45-53. [Abstract]



Jafar-Nejad H, Acar M, Nolo R, Lacin H, Pan H, Parkhurst SM, Bellen HJ (2003) Senseless acts as a binary switch during sensory organ precursor selection. Genes and Development 17:2966-2978. [Article]

Fabian-Fine R, Verstreken P, Hiesinger PR, Horne JA, Kostyleva R, Zhou Y, Bellen HJ, Meinertzhagen IA (2003) Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals. Journal of Neuroscience 23:10732-10744. [Abstract]

Verstreken P, Koh TW, Schulze KL, Zhai RG, Hiesinger PR, Zhou Y, Mehta SQ, Cao Y, Roos J, Bellen HJ (2003) Synaptojanin is recruited by Endophilin to promote synaptic vesicle uncoating. Neuron 40:733-748. [Abstract] [Faculty of 1000]

Zhai RG, Hiesinger PR, Koh TW, Verstreken P, Schulze KL, Cao Y, Jafar-Nejad H, Norga KK, Pan H, Bayat V, Greenbaum MP, Bellen HJ (2003) Mapping Drosophila mutations with molecularly defined P element insertions. Proceedings of the National Academy of Sciences USA 100:10860-10865. [Article] [Faculty of 1000]

Norga KK, Gurganus, MC, Dilda, CL, Yamamoto A, Lyman RF, Patel PH, Rubin GM, Hoskins RA, Mackay TF, Bellen HJ (2003) Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development. Current Biology 13:1388-1396. [Abstract] [Faculty of 1000]

Koh TW, Bellen HJ (2003) Synaptotagmin I, a Ca2+ sensor for neurotransmitter release. Trends in Neurosciences 26:413-422. [Abstract]

Wallis D, Hamblen M, Zhou Y, Venken KJT, Schumacher A, Grimes HL, Zoghbi HY, Orkin SH, Bellen HJ (2003) The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development 130:221-232. [Abstract] [Faculty of 1000]



Kango-Singh M, Nolo R, Tao C, Verstreken P, Hiesinger PR, Bellen HJ, Halder G (2002) Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 129:5719-5730. [Abstract]

Kjærulff O, Verstreken P, Bellen HJ (2002) Synaptic vesicle retrieval: still time for a kiss. Nature Cell Biology 4:245-248. [Abstract]

Wang V, Hassan BA, Bellen HJ, Zoghbi HY (2002) Drosophila atonal fully rescues the phenotype of Math1 null mice: new functions evolve in new cellular contexts. Current Biology 12:1611-1616. [Abstract]

Jafar-Nejad H, Norga KK, Bellen HJ (2002) Numb: "Adapting" Notch for endocytosis. Developmental Cell 3:155-156. [Abstract]

Pennetta G, Hiesinger PR, Fabian-Fine R, Meinertzhagen IA, Bellen HJ (2002) Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner. Neuron 35:291-306. [Abstract]

Verstreken P, Bellen HJ (2002) Meaningless minis? Mechanisms of neurotransmitter-receptor clustering. Trends in Neurosciences 25:383-385. [Abstract]

Seto ES, Bellen HJ, Lloyd TE (2002) When cell biology meets development: endocytic regulation of signaling pathways. Genes and Development 16:1314-1336. [Abstract]

Verstreken P, Kjærulff O, Lloyd TE, Atkinson R, Zhou Y, Meinertzhagen IA, Bellen HJ (2002) Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release. Cell 109:101-112. [Abstract] [Faculty of 1000]

Izaddoost S, Nam SC, Bhat M, Bellen HJ, Choi KW (2002) Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres. Nature 416:178-183. [Abstract] [Faculty of 1000]

Lloyd TE, Atkinson R, Wu MN, Zhou Y, Pennetta G, Bellen HJ (2002) Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell 108:261-269. [Abstract] [Faculty of 1000]

Chen S, Zheng X, Schulze KL, Li Q, Morris T, Bellen HJ, Stanley EF (2002) Enhancement of presynatic calcium current by cysteine string protein. Journal of Physiology 538:383-389. [Article]

Peter A, Schöttler P, Werner M, Beinert N, Dowe G, Burkert P, Mourkioti F, Dentzer L, He Y, Deák P, Benos PV, Gatt MK, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demaille J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Miñana B, Kafatos FC, Bolshakov S, Sidén-Kiamos I, Papagiannakis G, Spanos L, Louis C, Madueño E, de Pablos B, Modolell J, Bucheton A, Callister D, Campbell L, Henderson NS, McMillan PJ, Salles C, Tait E, Valenti P, Saunders RD, Billaud A, Pachter L, Klapper R, Janning W, Glover DM, Ashburner M, Bellen HJ, Jäckle, H, Schäfer U (2002) Mapping and identification of essential gene functions on the X-chromosome of Drosophila. EMBO Reports 3:34-38. [Article]



Fergestad T, Wu MN, Schulze KL, Lloyd TE, Bellen, HJ, Broadie K (2001) Targeted mutations in the syntaxin H3 domain specifically disrupt SNARE complex function in synaptic transmission. Journal of Neuroscience 21:9142-9150. [Abstract]

Frankfort BJ, Nolo R, Zhang Z, Bellen HJ, Mardon G (2001) senseless repression of rough is required for R8 photoreceptor differentiation in the developing Drosophila eye. Neuron 32:403-414. [Abstract] [Faculty of 1000]

Lloyd TE, Bellen HJ (2001) pRIMing synaptic vesicles for fusion. Nature Neuroscience 4:965-966. [Abstract]

Verstreken P, Bellen HJ (2001) The meaning of a mini. Science 293:443-444. [Abstract]

Bermingham NA, Hassan BA, Wang VY, Fernandez M, Banfi S, Bellen HJ, Fritzsch B, Zoghbi HY (2001) Proprioceptor pathway development is dependent on Math1. Neuron 30:411-422. [Abstract]

Bhat MA, Rios JC, Lu Y, Garcia-Fresco GP, Ching W, St. Martin M, Li J, Einheber S, Chesler M, Rosenbluth J, Salzer JL, Bellen HJ (2001) Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron 30:369-383. [Abstract]

Beckstead R, Ortiz JA, Sanchez C, Prokopenko SN, Chambon P, Losson R, Bellen HJ (2001) Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit betaFTZ-F1-dependent transcription. Molecular Cell 7:753-765. [Abstract]

Wu MN, Schulze KL, Lloyd TE, Bellen HJ (2001) The ROP-syntaxin interaction inhibits neurotransmitter release. European Journal of Cell Biology 80:196-199. [Abstract]

Steffensen S, Coelho PA, Cobbe N, Vass S, Costa M, Hassan B, Prokopenko SN, Bellen HJ, Heck MM, Sunkel CE (2001) A role for Drosophila SMC4 in the resolution of sister chromatids in mitosis. Current Biology 11:295-307. [Abstract]

Nolo R, Abbott LA, Bellen HJ (2001) Drosophila Lyra mutations are gain-of-function mutations in senseless. Genetics 157:307-315. [Article]



Prokopenko SN, He Y, Lu Y, Bellen HJ (2000) Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics 156:1691-1715. [Abstract] [PDF]

Nolo R, Abbott LA, Bellen HJ (2000) Senseless, a Zn-finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell 102:349-362. [Abstract] [PDF]

Hassan B, Bellen HJ (2000) Doing the MATH: is the mouse a good model system for Drosophila development? Genes and Development 14:1852-1865. [Abstract] [PDF]

Lloyd T, Verstreken P, Ostrin EJ, Phillipi A, Lichtarge O, Bellen HJ (2000) A genome-wide search for synaptic vesicle cycle proteins in Drosophila. Neuron 26:45-50. [Abstract] [PDF]

Hassan BA, Bermingham NA, He Y, Sun Y, Jan YN, Zoghbi HY, Bellen HJ (2000) atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain. Neuron 25:549-561. [Abstract] [PDF]

Prokopenko SN, Saint R, Bellen HJ (2000) Untying the Gordian knot of cytokenisis: role of small G proteins and their regulators. Journal of Cell Biology 148:843-848. [Abstract] [PDF]

Mao Y, Nickitenko A, Duan X, Lloyd T, Wu MN, Bellen HJ, Quiocho FA (2000) Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction. Cell 100:447-456. [Abstract] [PDF]

Ben-Arie N, Hassan BA, Bermingham NA, Armstrong D, Matzuk M, Bellen HJ, Zoghbi HY (2000) Functional conservation of atonal and Math1 in the CNS and PNS. Development 127:1039-1048. [Abstract] [PDF]

Prokopenko SN, Saint R, Bellen HJ (2000) Tissue distribution of PEBBLE RNA and Pebble protein during Drosophila embryonic development. Mechanisms of Development 90:269-273. [Abstract] [PDF]

Bellen HJ, Budnik V (2000) The Neuromuscular Junction. In Drosophila protocols. Editors: M. Ashburner, S. Hawley and B. Sullivan. Cold Spring Harbor Laboratory Press, New York. [LC Record]

Bellen HJ (2000) The fruitfly neuromuscular junction flexes its muscle. Cell 101:141-143. [PDF]



Pennetta G, Wu MN, Bellen HJ (1999) Dissecting the molecular mechanisms of neurotransmitter release in Drosophila. In Neurotransmitter release. Frontiers in Molecular Biology. Oxford University Press, New York, pp. 304-351. [LC Record]

Lloyd T, Bellen HJ (1999) Genetic analysis of neurotransmitter release in mice and humans. In Neurotransmitter release. Frontiers in Molecular Biology. Oxford University Press, New York, pp. 352-388. [LC Record]

Bellen HJ (1999) Ten years of enhancer detection: lessons from the fly. Plant Cell 11:2271-2282. [Abstract] [PDF]

Prokopenko SN, Brumby A, O'Keefe L, Prior L, He Y, Saint R, Bellen HJ (1999) A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes and Development 13: 2301-2314. [Abstract] [PDF]

Wu MN, Fergestad T, Lloyd T, He Y, Broadie K, Bellen HJ (1999) Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo. Neuron 23:593-605. [Abstract] [PDF]

Zhang B, Ganetzky B, Bellen HJ, Murthy VM (1999) Tailoring uniform coats for synaptic vesicles during endocytosis. Neuron 23:419-422. [Abstract] [PDF]

Bermingham NA, Hassan B, Price SD, Vollrath MA, Ben-Arie N, Eatock RA, Bellen HJ, Lysakowski A, Zoghbi HY (1999) Math1, an essential gene for the generation of inner ear hair cells. Science 284:1837-1841. [Abstract] [PDF]

Bhat M, Izadoost S, Lu Y, Cho KO, Choi KW, Bellen HJ (1999) Discs lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Cell 96:833-845. [Abstract] [PDF]



Zhang B, Koh YH, Beckstead RB, Budnik V, Ganetzky B, Bellen HJ (1998) Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis. Neuron 21:1465-1475. [Abstract] [PDF]

Hassan BA, Prokopenko SN, Breuer S, Zhang B, Paululat A, Bellen HJ (1998) skittles, a Drosophila phosphatidylinositol 4-phosphate 5-kinase, is required for cell viability, germline development and bristle morphology, but not for neurotransmitter release. Genetics 150:1527-1537. [Abstract] [PDF]

Bellen HJ, Lu Y, Beckstead R, Bhat MA (1998) Neurexin IV, caspr and paranodin--novel members of the neurexin family: encounters of axons and glia. Trends in Neurosciences 21:444-449. [Abstract] [PDF]

Bellen HJ (1998) The fruit fly: a model organism to study the genetics of alcohol abuse and addiction? Cell 93:909-912. [Abstract] [PDF]

Dye CA, Lee JK, Atkinson RC, Brewster R, Han PL, Bellen HJ (1998) The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein. Development 125:1845-1856. [Abstract] [PDF]

Adams RR, Tavares AA, Salzberg A, Bellen HJ, Glover DM (1998) pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis. Genes and Development 12:1483-1494. [Abstract] [PDF]

Wu MN, Littleton JT, Bhat MA, Prokop A, Bellen HJ (1998) ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner. EMBO Journal 17:127-139. [Abstract] [PDF]



Wu MN, Bellen HJ (1997) Genetic dissection of synaptic transmission in Drosophila. Current Opinion in Neurobiology 7:624-630. [Abstract] [PDF]

Cabello OA, Baldini A, Bhat M, Bellen H, Belmont JW (1997) Localization of BRRN1, the human homologue of Drosophila barr, to 2q11.2. Genomics 46:311-313. [Abstract] [PDF]

Salzberg A, Prokopenko SN, He Y, Tsai P, Pál M, Maróy P, Glover DM, Deák P, Bellen HJ (1997) P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: mutations affecting embryonic PNS development. Genetics 147:1723-1741. [Abstract] [PDF]

Ben-Arie N, Bellen HJ, Armstrong DL, McCall AE, Gordadze PR, Guo Q, Matzuk MM, Zoghbi HY (1997) Math1 is essential for genesis of cerebellar granule neurons. Nature 390:169-172. [Abstract] [PDF]

Littleton JT, Bhat MA, Bellen HJ (1997) Deciphering the function of neurexins at cellular junctions. Journal of Cell Biology 137:793-796. [Abstract] [PDF]



Bhat MA, Philp AV, Glover DM, Bellen HJ (1996) Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II. Cell 87:1103-1114. [Abstract] [PDF]

Baumgartner S, Littleton JT, Broadie K, Bhat MA, Harbecke R, Lengyel JA, Chiquet-Ehrismann R, Prokop A, Bellen HJ (1996) A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. Cell 87:1059-1068. [Abstract] [PDF]

Schulze KL, Bellen HJ (1996) Drosophila syntaxin is required for cell viability and may function in membrane formation and stabilization. Genetics 144:1713-1724. [Abstract] [PDF]

Salzberg A, Golden K, Bodmer R, Bellen HJ (1996) gutfeeling, a Drosophila gene encoding an antizyme-like protein, is required for late differentiation of neurons and muscles. Genetics 144:183-196. [Abstract] [PDF]

Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ, Zoghbi HY (1996) Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. Human Molecular Genetics 5:1207-1216. [Abstract] [PDF]

Rodriguez A, Zhou Z, Tang ML, Meller S, Chen J, Bellen H, Kimbrell DA (1996) Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster. Genetics 143:929-940. [Abstract] [PDF]

Salzberg A, Bellen HJ (1996) Invertebrate versus vertebrate neurogenesis: variations on the same theme? Developmental Genetics 18:1-10. [Abstract] [PDF]



Littleton JT, Bellen HJ (1995) Presynaptic proteins involved in exocytosis in Drosophila melanogaster: a genetic analysis. Invertebrate Neuroscience 1:3-13. [Abstract] [PDF]

Bellen HJ, Smith RF (1995) FlyBase: a virtual Drosophila cornucopia. Trends in Genetics 11:456-457. [Abstract] [PDF]

Broadie K, Prokop A, Bellen HJ, O'Kane CJ, Schulze KL, Sweeney ST (1995) Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila. Neuron 15:663-673. [Abstract] [PDF]

Kania A, Salzberg A, Bhat M, D'Evelyn D, He Y, Kiss I, Bellen HJ (1995) P-element mutations affecting embryonic peripheral nervous system development in Drosophila melanogaster. Genetics 139:1663-1678. [Abstract] [PDF]

Littleton JT, Bellen HJ (1995) Synaptotagmin controls and modulates synaptic-vesicle fusion in a Ca2+-dependent manner. Trends in Neurosciences 18:177-183. [Abstract] [PDF]

Schulze KL, Broadie K, Perin MS, Bellen HJ (1995) Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission. Cell 80:311-320. [Abstract] [PDF]

Kania A, Bellen HJ (1995) Neuromusculin, an Ig-like protein, is required for proper CNS and PNS development in Drosophila. Roux's Archives of Developmental Biology 204:259-269. [Abstract] [PDF]



Littleton JT, Stern M, Perin M, Bellen HJ (1994) Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants. Proceedings of the National Academy of Sciences USA 91:10888-10892. [Abstract] [PDF]

Schulze KL, Littleton JT, Salzberg A, Halachmi N, Stern M, Lev Z, Bellen HJ (1994) rop, a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo. Neuron 13:1099-1108. [Abstract] [PDF]

Broadie K, Bellen HJ, DiAntonio A, Littleton JT, Schwarz TL (1994) Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission. Proceedings of the National Academy of Sciences USA 91:10727-10731. [Abstract] [PDF]

Littleton JT, Bellen HJ (1994) Genetic and phenotypic analysis of thirteen essential genes in cytological interval 22F1-2; 23B1-2 reveals novel genes required for neural development in Drosophila. Genetics 138:111-123. [Abstract] [PDF]

Salzberg A, D'Evelyn D, Schulze KL, Lee JK, Strumpf D, Tsai L, Bellen HJ (1994) Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13:269-287. [Abstract] [PDF]

Eldon E, Kooyer S, D'Evelyn D, Duman M, Lawinger P, Botas J, Bellen H (1994) The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll. Development 120:885-899. [Abstract] [PDF]



Kania A, Han PL, Kim YT, Bellen H (1993) neuromusculin, a Drosophila gene expressed in peripheral neuronal precursors and muscles, encodes a cell adhesion molecule. Neuron 11:673-687. [Abstract] [PDF]

Littleton JT, Stern M, Schulze K, Perin M, Bellen HJ (1993) Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca2+-activated neurotransmitter release. Cell 74:1125-1134. [Abstract] [PDF]

Littleton JT, Bellen HJ, Perin MS (1993) Expression of Synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse. Development 118:1077-1088. [Abstract] [PDF]



Bellen HJ, Kooyer S, D'Evelyn D, Pearlman J (1992) The Drosophila couch potato protein is expressed in nuclei of peripheral neuronal precursors and shows homology to RNA-binding proteins. Genes and Development 6:2125-2136. [Abstract] [PDF]

Bellen HJ, Vaessin H, Bier E, Kolodkin A, D'Evelyn D, Kooyer S, Jan YN (1992) The Drosophila couch potato gene: an essential gene required for normal adult behavior. Genetics 131:365-375. [Abstract] [PDF]

Bellen HJ, D'Evelyn D, Harvey M, Elledge SJ (1992) Isolation of temperature-sensitive diphtheria toxins in yeast and their effects on Drosophila cells. Development 114:787-796. [Abstract] [PDF]