Bellen Lab

Zhongyuan (Zach) Zuo

Zhongyuan (Zach) Zuo

BS, University of Denver, CO
MS, University of Denver, CO

Personal Summary

Experienced Confocal and Transmission Electron Microscopist at the Baylor College of Medicine with an 8+ years history of working in the Biological research field. Skilled in project management, Histology, Molecular Biology, Data Analysis, Confocal Microscopy, and Transmission Electron Microscopy. Daily website/database management and update. Download CV


Publications

Martelli F, Zuo Z, Wang J, Wong CO, Karagas NE, Roessner U, Rupasinhe T, Venkatachalam K, Perry T, Batterham P, Bellen HJ (2021) Low doses of the organic insecticide spinosad trigger lysosomal defects, ROS driven lipid dysregulation and neurodegeneration in flies. bioRxiv :.   
Cunningham K, Zhang K, Maulding K, Senturk M, Grima J, Sung H, Zuo Z, Song H, Rothstein J, Bellen HJ (2020) TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS. eLife 9:e59419.  [Abstract]
Martelli F, Zuo Z, Wang J, Wong CO, Karagas NE, Roessner U, Rupasinghe T, Venkatachalam K, Perry T, Bellen HJ, Batterham P (2020) Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in DrosophilaPNAS 117:25840-25850.  [Abstract]
Ding X, Jo J, Wang CY, Cristobal CD, Zuo Z, Ye Q, Wirianto M, Lindeke-Myers A, Choi JM, Mohila CA, Kawabe H, Jun SY, Bellen HJ, Yoo SH, Lee HK (2020) The Daam2-VHL-Nedd4 Axis 1 Governs Developmental and Regenerative Oligodendrocyte Differentiation. Genes and Development 34 (17-18):1177-1189.  [Abstract]
Li X, Yang L, Mao Z, Pan X, Zhao Y, Gu X, Eckel-mahan K, Zuo Z, Tong Q, Hartig SM, Cheng X, Du G, Moore DD, Bellen HJ, Sesaki H, Sun K (2020) Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue. The FASEB Journal 34(6):8265-8282.  [Abstract]
Ye H, Ojelade SA, Li-Kroeger D, Zuo Z, Wang L,Y Li, Gu JYJ, Tepass U, Rodal AA, Bellen HJ, Shulman JM (2020) Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain. eLife 9:e91577.  [Abstract]
Chung HL, Wangler MF, Marcogliese PC, Jo J, Ravenscroft TA, Zuo Z, Duraine L, Sadeghzadeh S, Li-Kroeger D, Schmidt RE, Pestronk A, Rosenfeld JA, Burrage L, Herndon MJ, Chen S, Undiagnosed Diseases Network, Shillington A, Vawter-Lee M, Hopkin R, Rodriguez-Smith J, Henrickson M, Lee B, Moser AB, Jones RO, Watkins P, Yoo T, Mar S, Choi M, Bucelli RC, Yamamoto S, Lee HK, Prada CE, Chae JH, Vogel TP, Bellen HJ (2020) Loss or gain of function mutations in ACOX1 cause axonal loss via different mechanisms. Neuron 106:589-606.  [Abstract]
Wang J, Rousseau J, Kim E, Ehresmann S, Cheng YT, Duraine L, Zuo Z, Park YJ, Li-Kroeger D, Bi W, Wong LJ, Rosenfeld J, Gleeson J, Faqeih E, Alkuraya FS, Wierenga KJ, Chen J, Afenjar A, Nava C, Doummar D, Keren B, Juusola J, Grompe M, Bellen HJ, Campeau PM (2019) Loss of Oxidation Resistance 1, OXR1, is associated with an autosomal-recessive eurological disease with cerebellar atrophy and lysosomal dysfunction. American Journal of Human Genetics 105:1237-1253.  [Abstract]
Kanca O, Zirin J, Garcia-Marques J, Knight SM, Yang-Zhou D, Amador G, Chung HL, Zuo Z, Ma L, He Y, Lin WW, Fang Y, Ge M, Yamamoto S, Schulze KL, Hu Y, Spradling AC, Mohr SE, Perrimon N, Bellen HJ (2019) An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms. eLife 8:e51539.  [Abstract]
Ojelade SA, Lee TV, Giagtzoglou N, Yu L, Ugur B, Li Y, Duraine L, Zuo Z, Petyuk V, De Jager PL, Bennett DS, Arenkiel BR, Bellen HJ, Shulman JM (2019) cindr, the Drosophila homolog of the CD2AP Alzheimer's disease susceptibility gene, is required for synaptic transmission and proteostasis. Cell Reports 28:1799-1813.  [Abstract]
Şentürk M, Lin G, Mao D, Zuo Z, Watson E, Mikos AG, Bellen HJ (2019) Ubiquilins regulate autophagic flux through mTOR signaling and lysosomal acidification. Nature Cell Biology 21:384-396.  [Abstract]
Brown AM, Arancillo M, Lin T, Catt DR, Zhou J, Lackey EP, Stay TL, Zuo Z, White JJ, Sillitoe RV. (2019) Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells. Scientific Reports 9:1-19.  [Abstract]
Mao D, Lin G, Tepe B, Zuo Z, Tan KL, Senturk M, Zhang S, Arenkiel BR, Sardiello M, Bellen HJ (2019) VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway. Autophagy 11:1-20.  [Abstract]
Li-Kroeger D, Kanca O, Lee PT, Cowan S, Lee MT, Jaiswal M, Salazar JL, He Y, Zuo Z, Bellen HJ (2018) An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in DrosophilaeLife 7:e38709.  [Abstract]
Marcogliese PC, Shashi V, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Martínez-Agosto JA, Herzog M, Chen AH, Dickson PI, Lin HJ, Vera MU, Salamon N, Graham JM Jr, Ortiz D, Infante E, Steyaert W, Dermaut B, Poppe B, Chung HL, Zuo Z, Lee PT, Kanca O, Xia F, Yang Y, Smith EC, Jasien J, Kansagra S, Spiridigliozzi G, El-Dairi M, Lark R, Riley K, Koeberl DD, Golden-Grant K; Program for Undiagnosed Diseases (UD-PrOZA); Undiagnosed Diseases Network, Yamamoto S, Wangler MF, Mirzaa G, Hemelsoet D, Lee B, Nelson SF, Goldstein DB, Bellen HJ, Pena LDM (2018) IRF2BPL is associated with neurological phenotypes. American Journal of Human Genetics 103:245-260.  [Abstract]
Lin G, Lee PT, Chen K, Mao D, Tan KL, Zuo Z, Lin WW, Wang L, Bellen HJ (2018) Phospholipase PLA2G6, a Parkinsonism-associated gene, affects Vps26 and Vps35, retromer function, and ceramide levels, similar to α-Synuclein gain. Cell Metabolism 28:605-618.  [Abstract]
Lee PT, Zirin J, Kanca O, Lin WW, Schulze KL, Li-Kroeger D, Tao R, Devereaux C, Hu Y, Chung V, Fang Y, He Y, Pan H, Ge M, Zuo Z, Housden BE, Mohr SE, Yamamoto S, Levis RW, Spradling AC, Perrimon N, Bellen HJ (2018) A gene-specific T2A-GAL4 library for DrosophilaeLife 7:e35574.  [Abstract]
Ugur B, Bao H, Stawarski M, Duraine LR, Zuo Z, Lin YQ, Neely GG, Macleod GT, Chapman ER, Bellen HJ (2017) The Krebs cycle enzyme Isocitrate Dehydrogenase 3A couples mitochondrial metabolism to synaptic transmission. Cell Reports 21:3794-3806.  [Abstract]
Luo X, Rosenfeld JA, Yamamoto S, Harel T, Zuo Z, Hall M, Wierenga KJ, Pastore MT, Bartholomew D, Delgado MR, Rotenberg J, Lewis RA, Emrick L, Bacino CA, Eldomery MK, Coban Akdemir Z, Xia F, Yang Y, Lalani SR, Lotze T, Lupski JR, Lee B, Bellen HJ, Wangler MF; Members of the UDN (2017) Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially. PLoS Genetics 13:e1006905.  [Abstract]
Nagarkar-Jaiswal S, Manivannan SN, Zuo Z, Bellen HJ (2017) A cell cycle-independent, conditional gene inactivation strategy for differentially tagging wild-type and mutant cells. eLife 6:e26420.  [Abstract]
Chouhan AK, Guo C, Hsieh YC, Ye H, Senturk M, Zuo Z, Li Y, Chatterjee S, Botas J, Jackson GR, Bellen HJ, Shulman JM (2016) Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease. Acta Neuropathologica Communications 4:62.  [Abstract]
Mavor LM, Miao H, Zuo Z, Holly RM, Xie Y, Loerke D, Blankenship JT (2016) Rab8 directs furrow ingression and membrane addition during epithelial formation in Drosophila melanogasterDevelopment 143:892-903.  [Abstract]
David-Morrison G, Xu Z, Rui YN, Charng WL, Jaiswal M, Yamamoto S, Xiong B, Zhang K, Sandoval H, Duraine L, Zuo Z, Zhang S, Bellen HJ (2016) WAC regulates mTOR activity by acting as an adaptor for the TTT and Pontin/Reptin complexes. Developmental Cell 36:139-151.  [Abstract]
Nagarkar-Jaiswal S, DeLuca SZ, Lee PT, Lin WW, Pan H, Zuo Z, Lv J, Spradling AC, Bellen HJ (2015) A genetic toolkit for tagging intronic MiMIC containing genes. eLife 4:e08469.  [Abstract]
Holly RM, Mavor LM, Zuo Z, Blankenship JT (2015) A rapid, membrane-dependent pathway directs furrow formation through RalA in the early Drosophila embryo. Development 142:2316-2328.  [Abstract]

Last Modified 3-31-21 by Jodie Hebert

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