Bellen Lab

Yan Huang

Yan Huang

BS, Hunan Agricultural University, China
MS, Hunan Agricultural University, China
PhD, University of Chinese Academy of Sciences, China (Yong Q. Zhang)

Research Interests

I am interested in unraveling the molecular pathways that underlie rare genetic neurological diseases in infants using Drosophila as a model organism. The fly allows us to efficiently study and analyze the underlying pathogenic mechanisms of these genetic diseases. An in-depth investigation of the affected cellular and molecular pathways allows us to identify molecular targets and sometimes existing drugs that affect these targets and hence allow therapeutic development. These studies often also shed light on much more common diseases like Parkinson's Disease, Alzheimer Disease and Multiple Sclerosis.


Publications

Huang Y, Huang S, Di Scala C, Wang Q, Wandall HH, Fantini J, Zhang YQ (2018) The glycosphingolipid MacCer promotes synaptic bouton formation in Drosophila by interacting with Wnt. eLife 7:e38183.  [Abstract]
Huang Y, Huang S, Lam SM, Liu Z, Shui G, Zhang YQ (2016) Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids. Journal of Cell Science 129:4034-4045.  [Abstract]
Liu Z*, Huang Y*, Hu W, Huang S, Wang Q, Han J, Zhang YQ (2014) dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling. Journal of Neuroscience 34:2785-2796. (*equal contribution) [Abstract]
Liu Z, Huang Y, Zhang Y, Chen D, Zhang YQ (2011) Drosophila Acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission. Journal of Neuroscience 31:2052-2063.  [Abstract]

Bellen Lab
1250 Moursund St., Suite N1125 - Houston, TX 77030

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