Xi Luo

Xi Luo

Research Interests

The Undiagnosed Diseases Network (UDN) aims to bring together clinical and research experts from across the United States to solve the most challenging medical mysteries using advanced technologies. The Simons Foundation Autism Research Initiative (SFARI) funds innovative research to improve the understanding, diagnosis and treatment of autism spectrum disorders. I am a member of the UDN-SFARI team at the Drosophila Core (DC) of the Model Organism Screening Center (MOSC). My goal is to take advantage of our cumulative knowledge and expertise as well as novel technologies and resources to provide in vivo functional information for evolutionarily conserved genes and determine the potential pathogenicity of variants found in UDN and SFARI patients. In addition, I am particularly interested in characterizing the importance of the patients' mutations in the protein structure to provide critical insights into the molecular mechanisms and biological pathways underlying human rare diseases.


Luo X*, Rosenfeld JA*, Yamamoto S, Harel T, Zuo Z, Hall M, Wierenga KJ, Pastore MT, Bartholomew D, Delgado MR, Rotenberg J, Lewis RA, Emrick L, Bacino CA, Eldomery MK, Coban Akdemir Z, Xia F, Yang Y, Lalani SR, Lotze T, Lupski JR, Lee B, Bellen HJ, Wangler MF; Members of the UDN (2017) Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially. PLoS Genetics 13:e1006905. (*equal contribution) [Abstract]
Luo X, Wasilko DJ, Liu Y, Sun J, Wu X, Luo ZQ, Mao Y (2015) Structure of the Legionella virulence factor, SidC reveals a unique PI(4)P-specific binding domain essential for its targeting to the bacterial phagosome. PLoS Pathogens 11:e1004965.  [Abstract]
Hsu F*, Luo X*, Qiu J*, Teng YB, Jin J, Smolka MB, Luo ZQ, Mao Y (2014) The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling. Proceedings of the National Academy of Sciences USA 111:10538-10543. (*equal contribution) [Abstract]
Xing W, Zou Y, Liu Q, Liu J, Luo X, Huang Q, Chen S, Zhu L, Bi R, Hao Q, Wu JW, Zhou JM, Chai J (2007) The structural basis for activation of plant immunity by bacterial effector protein AvrPto. Nature 449:243-247.  [Abstract]