Thomas Ravenscroft

Thomas Ravenscroft

Research Interests

Neurodegenerative diseases arrise from a multitude of different causes, and can originate in various locations within the nervous system to cause harm. I am interested in understanding what causes certain neuronal populations to have an increased vulnerability to different insults whether they be genetic or environmental. Using the exciting genetic tools at our disposal in Drosophila melanogaster, I aim to learn more about the variances between neuronal populations in terms of their architecture, composition and physiology. Using a common component of all neurons, the sodium channel gene para, and selective targeting of neurons using the UAS-GAL4 system, I aim to identify the components that are unique to specific neurons as well as the consequences when these neurons are depleted.


Pottier C, Ravenscroft TA, Brown PH, Finch NA, Baker M, Parsons M, Asmann YW, Ren Y, Christopher E, Levitch D, van Blitterswijk M, Cruchaga C, Campion D, Nicolas G, Richard AC, Guerreiro R, Bras JT, Zuchner S, Gonzalez MA, Bu G, Younkin S, Knopman DS, Josephs KA, Parisi JE, Petersen RC, Ertekin-Taner N, Graff-Radford NR, Boeve BF, Dickson DW, Rademakers R (2016) TYROBP genetic variants in early-onset Alzheimer's disease. Neurobiology of Aging 48:222.  [Abstract]
Ravenscroft TA, Pottier C, Murray ME, Baker M, Christopher E, Levitch D, Brown PH, Barker W, Duara R, Greig-Custo M, Betancourt A, English M, Sun X, Ertekin-Taner N, Graff-Radford NR, Dickson DW, Rademakers R (2016) The presenilin 1 p.Gly206Ala mutation is a frequent cause of early-onset Alzheimer's disease in Hispanics in Florida. American Journal of Neurodegenerative Disease 5:94-101.  [Abstract]
Pottier C, Ravenscroft TA, Sanchez-Contreras M, Rademakers R (2016) Genetics of FTLD: overview and what else we can expect from genetic studies. Journal of Neurochemistry 138 Suppl 1:32-53.  [Abstract]
Rodriguez-Porcel F, Lowder L, Rademakers R, Ravenscroft T, Ghetti B, Hagen MC, Espay AJ (2016) Fulminant corticobasal degeneration: Agrypnia excitata in corticobasal syndrome. Neurology 86:1164-1166.  [Abstract]
Pottier C, Bieniek KF, Finch N, van de Vorst M, Baker M, Perkersen R, Brown P, Ravenscroft T, van Blitterswijk M, Nicholson AM, DeTure M, Knopman DS, Josephs KA, Parisi JE, Petersen RC, Boylan KB, Boeve BF, Graff-Radford NR, Veltman JA, Gilissen C, Murray ME, Dickson DW, Rademakers R (2015) Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease. Acta Neuropathologica 130:77-92.  [Abstract]
Kertesz A, Finger E, Murrell J, Chertkow H, Ang LC, Baker M, Ravenscroft T, Rademakers R, Munoz DG (2015) Progressive supranuclear palsy in a family with TDP-43 pathology. Neurocase 21:178-184.  [Abstract]
van Blitterswijk M, Baker MC, DeJesus-Hernandez M, Ghidoni R, Benussi L, Finger E, Hsiung GY, Kelley BJ, Murray ME, Rutherford NJ, Brown PE, Ravenscroft T, Mullen B, Ash PE, Bieniek KF, Hatanpaa KJ, Karydas A, Wood EM, Coppola G, ..., Dickson DW, Rademakers R (2013) C9ORF72 repeat expansions in cases with previously identified pathogenic mutations. Neurology 81:1332-1341.  [Abstract]
Ravenscroft TA, Baker MC, Rutherford NJ, Neumann M, Mackenzie IR, Josephs KA, Boeve BF, Petersen R, Halliday GM, Kril J, van Swieten JC, Seeley WW, Dickson DW, Rademakers R (2013) Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS. Neurobiology of Aging 34:2235.  [Abstract]