BS, Sichuan University, China PhD, Institute of Neuroscience, University of Chinese Academy of Sciences, China (Jiawei Zhou)
The fruit fly, Drosophila melanogaster, looks so different from humans. But most fundamental biological mechanisms and pathways are conserved between these species. Fruit fly has been proven as a valuable tool, enabling many important discoveries in neurological disease research. I'm interested in identifying genes involved in the undiagnosed diseases using fruit fly as a model organism. And also, I want to take advantage of this system to study the mechanisms underlying neurodegeneration, thus providing therapeutic strategies.
Lu SZ*, Guo YS, Liang PZ, Zhang SZ, Yin S, Yin YQ, Wang XM, Ding F, Gu XS, Zhou JW (2019) Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation. Translational Neurodegeneration 8:3. (*equal contribution) [Abstract]
Guo YS, Liang PZ, Lu SZ, Chen R, Yin YQ, Zhou JW (2019) Extracellular αB-crystallin modulates the inflammatory responses. Biochemical and Biophysical Research Communications 508:282-288. [Abstract]
Lu S, Zhou J (2017) Finding the 'Guilty' Gene Variant of Sporadic Parkinson's Disease Via CRISPR/Cas9. Neuroscience Bulletin 33:115-117. [Abstract]