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Scott Barish

Scott Barish



Research Interests

I am interested in modeling disease to uncover the fundamental mechanisms of neuronal biology. Currently, I use the fly eye as model for Alzheimer's Disease to understand how neurons age and respond to oxidative stress. Our lab has shown that oxidative stress causes neurons to produce peroxidated lipids that are shuttles to nearby glial cells and packaged into lipid droplets. In order to better understand this pathway, I am investigating known Alzheimer's Disease risk genes that may be involved in lipid export from neurons. I am also working to understand how chromatin modifying proteins lead to neurodevelopmental disorders.


Publications

Barish S, Nuss S, Strunilin I, Bao S, Mukherjee S, Jones CD, Volkan PC (2018) Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila. PLoS Genetics 14:e1007560.  [Abstract]
Barish S, Volkan PC (2018) Preparing developing peripheral olfactory tissue for molecular and immunohistochemical analysis in Drosophila. Journal of Visualized Experiments: JoVE 2018 Jun 13:(136).  [Abstract]
Pan JW, Li Q, Barish S, Okuwa S, Zhao S, Soeder C, Kanke M, Jones CD, Volkan PC (2017) Patterns of transcriptional parallelism and variation in the developing olfactory system of Drosophila species. Scientific Reports 7:8804.  [Abstract]
Barish S, Li Q, Pan JW, Soeder C, Jones C, Volkan PC (2017) Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates. Scientific Reports 7:40873.  [Abstract]
Li Q*, Barish S*, Okuwa S, Maciejewski A, Brandt AT, Reinhold D, Jones CD, Volkan PC (2016) A functionally conserved gene regulatory network module governing olfactory neuron diversity. PLoS Genetics 12:e1005780. (*equal contribution) [Abstract]
Li Q*, Barish S*, Okuwa S, Volkan PC (2015) Examination of endogenous Rotund expression and function in developing Drosophila olfactory system using CRISPR-Cas9-mediated protein tagging . G3 5:2809-2816. (*equal contribution) [Abstract]
Barish S, Volkan PC (2015) Mechanisms of olfactory receptor neuron specification in Drosophila. Wiley Interdiscipinary Reviews. Developmental Biology 4:609-621.  [Abstract]