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Pei-Tseng Lee

Pei-Tseng Lee



Research Interests

Reactive oxygen species (ROS) are common by-products generated mostly in mitochondria. Excess ROS cause biomolecule damage and will further lead to neurodegeneration. Many neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis are exacerbated by ROS. Oxidative stress due to ROS also contributes to aging, a major risk factor for neurodegenerative diseases. By feeding fruit flies with paraquat, a poison known to increase ROS, we can screen mutants for sensitivity to ROS. This systemic screen allows us to address the cellular mechanisms involved in the response to ROS and increase and assess their contribution to neurodegeneration.


Publications

Carrillo RA, Özkan E, Menon KP, Nagarkar-Jaiswal S, Lee PT, Jeon M, Birnbaum ME, Bellen HJ, Garcia KC, Zinn K (2015) Control of synaptic connectivity by a network of Drosophila IgSF cell surface proteins. Cell 163:1770-1782.  [Abstract]
Tan L, Zhang KX, Pecot MY, Nagarkar-Jaiswal S, Lee PT, Takemura SY, McEwen JM, Nern A, Xu S, Tadros W, Chen Z, Zinn K, Bellen HJ, Morey M, Zipursky SL (2015) Ig superfamily ligand and receptor pairs expressed in synaptic partners in Drosophila. Cell 163:1756-1769.  [Abstract]
Nagarkar-Jaiswal S, DeLuca SZ, Lee PT, Lin WW, Pan H, Zuo Z, Lv J, Spradling AC, Bellen HJ (2015) A genetic toolkit for tagging intronic MiMIC containing genes. eLife 4:e08469.  [Abstract]
Nagarkar-Jaiswal S, Lee PT, Campbell ME, Chen K, Anguiano-Zarate S, Cantu Gutierrez M, Busby T, Lin WW, He Y, Schulze KL, Booth BW, Evans-Holm M, Venken KJ, Levis RW, Spradling AC, Hoskins RA, Bellen HJ (2015) A library of MiMICs allows tagging of genes and reversible spatial and temporal knockdown of proteins in Drosophila. eLife 4:e05338.  [Abstract]
Wu CL, Shih MF, Lee PT, Chiang AS (2013) An octopamine-mushroom body circuit modulates the formation of anesthesia-resistant memory in Drosophila. Current Biology 23:2346-2354.  [Abstract]
Pai TP, Chen CC, Lin HH, Chin AL, Lai JS, Lee PT, Tully T, Chiang AS (2013) Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation. Proceedings of the National Academy of Sciences USA 110:7898-7903.  [Abstract]
Lee PT, Lin HW, Chang YH, Fu TF, Dubnau J, Hirsh J, Lee T, Chiang AS (2011) Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila. Proceedings of the National Academy of Sciences USA 108:13794-13799.  [Abstract]
Qiao X, Chuang BF, Jin Y, Muranjan M, Hung CH, Lee PT, Lee MG (2006) Sorting signals required for trafficking of the cysteine-rich acidic repetitive transmembrane protein in Trypanosoma bruceiEukaryotic Cell 5:1229-1242.  [Abstract]
Hung CH, Qiao X, Lee PT, Lee MG (2004) Clathrin-dependent targeting of receptors to the flagellar pocket of procyclic-form Trypanosoma bruceiEukaryotic Cell 3:1004-1014.  [Abstract]