Paul Marcogliese

Paul Marcogliese

Research Interests

I am interested in the discovery and characterization of novel genes involved in a variety of undefined neurological conditions. In attempts to streamline these efforts, I am part of the Undiagnosed Diseases Network (UDN). The UDN uses next-generation sequencing (whole-genome and whole-exome) to determine causative gene variants in these patients. This is followed by rapid generation of Drosophila with strong loss of function alleles in these genes. The characterization of these flies and further examination of the underlying molecular and cellular mechanisms underlying the phenotype in flies may provide vital insight into the human disease.


Yang J, Kim KS, Iyirhiaro GO, Marcogliese PC, Callaghan SM, Qu D, Kim WJ, Slack RS, Park DS (2019) DJ-1 modulates the unfolded protein response and cell death via upregulation of ATF4 following ER stress. Cell Death & Disease 10:135.  [Abstract]
Lin G, Wang L, Marcogliese PC, Bellen HJ (2018) Sphingolipids in the pathogenesis of Parkinson's disease and parkinsonism. Trends in Endocrinology & Metabolism 30:106-117.  [Abstract]
Marcogliese PC*, Shashi V*, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Martínez-Agosto JA, Herzog M, Chen AH, Dickson PI, Lin HJ, Vera MU, Salamon N, Graham JM Jr, Ortiz D, Infante E, Steyaert W, Dermaut B, Poppe B, Chung HL, Zuo Z, Lee PT, Kanca O, Xia F, Yang Y, Smith EC, Jasien J, Kansagra S, Spiridigliozzi G, El-Dairi M, Lark R, Riley K, Koeberl DD, Golden-Grant K; Program for Undiagnosed Diseases (UD-PrOZA); Undiagnosed Diseases Network, Yamamoto S, Wangler MF, Mirzaa G, Hemelsoet D, Lee B, Nelson SF, Goldstein DB, Bellen HJ, Pena LDM (2018) IRF2BPL is associated with neurological phenotypes. American Journal of Human Genetics 103:245-260. (*equal contribution) [Abstract]
Kim KS*, Marcogliese PC*, Yang J, Callaghan S, Resende V, Abdel-Messih E, Marras C, Visanji NP, Huang J, Schlossmacher MG, Trinkle-Mulcahy L, Slack RS, Lang AE, Canadian Lrrk2 in Inflammation Team (CLINT), Park DS (2018) Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease. Proceedings of the National Academy of Sciences USA 115:E5164-E5173. (*equal contribution) [Abstract]
Marcogliese PC, Wangler MF (2018) Drosophila as a model for human diseases. eLS 1:22 Jan 2018. [Article] 
Marcogliese PC, Abuaish S, Kabbach G, Abdel-Messih E, Seang S, Li G, Slack RS, Haque ME, Venderova K, Park DS (2017) LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in DrosophilaHuman Molecular Genetics 26:1247-1257.  [Abstract]
Qu D, Hage A, Don-Carolis K, Huang E, Joselin A, Safarpour F, Marcogliese PC, Rousseaux MW, Hewitt SJ, Huang T, Im DS, Callaghan S, Dewar-Darch D, Figeys D, Slack RS, Park DS (2015) BAG2 gene-mediated regulation of PINK1 protein is critical for mitochondrial translocation of PARKIN and neuronal survival. Journal of Biological Chemistry 290:30441-30452.  [Abstract]
Sanchez G, Varaschin RK, Büeler H, Marcogliese PC, Park DS, Trudeau LE (2014) Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice. PLoS One 9:e94826.  [Abstract]
Rousseaux MW, Marcogliese PC, Qu D, Hewitt SJ, Seang S, Kim RH, Slack RS, Schlossmacher MG, Lagace DC, Mak TW, Park DS (2012) Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease. Proceedings of the National Academy of Sciences USA 109:15918-15923.  [Abstract]
Aleyasin H, Rousseaux MW, Marcogliese PC, Hewitt SJ, Irrcher I, Joselin AP, Parsanejad M, Kim RH, Rizzu P, Callaghan SM, Slack RS, Mak TW, Park DS (2010) DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. Proceedings of the National Academy of Sciences USA 107:3186-3191.  [Abstract]