Oguz Kanca

Oguz Kanca

Research Interests

Whole exome sequencing and personalized medicine prompted the need for efficient methods to test the functionality of gene variants. I am interested in establishing techniques and tools to expedite the analysis of functionality of human gene variants, using the power of Drosophila genetics.


Kanca O, Bellen HJ, Schnorrer F (2017) Gene tagging strategies to assess protein expression, localization, and function in Drosophila. Genetics 207:389-412.  [Abstract]
Bieli D, Kanca O, Requena D, Hamaratoglu F, Gohl D, Schedl P, Affolter M, Slattery M, Müller M, Estella C (2015) Establishment of a developmental compartment requires interactions between three synergistic cis-regulatory modules. PLoS Genetics 11:e1005376.  [Abstract]
Denes AS, Kanca O, Affolter M (2015) A cellular process that includes asymmetric cytokinesis remodels the dorsal tracheal branches in Drosophila larvae. Development 142:1794-1805.  [Abstract]
Bieli D, Kanca O, Gohl D, Denes A, Schedl P, Affolter M, Müller M (2015) The Drosophila melanogaster mutants apblot and apXasta affect an essential apterous wing enhancer. G3 5:1129-1143.  [Abstract]
Kanca O, Ochoa-Espinosa A, Affolter M (2014) IV. Tools and methods for studying cell migration and cell rearrangement in tissue and organ development. Methods 68:228-232.  [Abstract]
Kanca O, Caussinus E, Denes AS, Percival-Smith A, Affolter M (2014) Raeppli: a whole-tissue labeling tool for live imaging of Drosophila development. Development 141:472-480.  [Abstract]
Caussinus E, Kanca O, Affolter M (2013) Protein knockouts in living eukaryotes using deGradFP and green fluorescent protein fusion targets. Current Protocols in Protein Science 73:Unit 30.2.  [Abstract]
Caussinus E, Kanca O, Affolter M (2011) Fluorescent fusion protein knockout mediated by anti-GFP nanobody. Nature Structural and Molecular Biology 19:117-121.  [Abstract]
Mitchell JS, Kanca O, McIntyre BW (2002) Lipid microdomain clustering induces a redistribution of antigen recognition and adhesion molecules on human T lymphocytes. Journal of Immunology 168:2737-2744.  [Abstract]