Oguz Kanca

Oguz Kanca

Research Interests

Whole exome sequencing and personalized medicine prompted the need for efficient methods to test the functionality of gene variants. I am interested in establishing techniques and tools to expedite the analysis of functionality of human gene variants, using the power of Drosophila genetics.


Marcogliese PC, Shashi V, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Martínez-Agosto JA, Herzog M, Chen AH, Dickson PI, Lin HJ, Vera MU, Salamon N, Ortiz D, Infante E, Steyaert W, Dermaut B, Poppe B, Chung HL, Zuo Z, Lee PT, Kanca O, Xia F, Yang Y, Smith EC, Jasien J, Kansagra S, Spiridigliozzi G, El-Dairi M, Lark R, Riley K, Koeberl DD, Golden-Grant K, Program for Undiagnosed Diseases (UD-PrOZA), Undiagnosed Diseases Network, Yamamoto S, Wangler MF, Mirzaa G, Hemelsoet D, Lee B, Nelson SF, Goldstein DB, Bellen HJ, Pena LDM (2018) Loss-of-function in IRF2BPL is associated with neurological phenotypes. BioRxiv 322495:Epub ahead of print.   
Lee PT, Zirin J, Kanca O, Lin WW, Schulze KL, Li-Kroeger D, Tao R, Devereaux C, Hu Y, Chung V, Fang Y, He Y, Pan H, Ge M, Zuo Z, Housden BE, Mohr SE, Yamamoto S, Levis RW, Spradling AC, Perrimon N, Bellen HJ (2018) A gene-specific T2A-GAL4 library for DrosophilaeLife 7:e35574.  [Abstract]
Kanca O, Bellen HJ, Schnorrer F (2017) Gene tagging strategies to assess protein expression, localization, and function in Drosophila. Genetics 207:389-412.  [Abstract]
Bieli D, Kanca O, Requena D, Hamaratoglu F, Gohl D, Schedl P, Affolter M, Slattery M, Müller M, Estella C (2015) Establishment of a developmental compartment requires interactions between three synergistic cis-regulatory modules. PLoS Genetics 11:e1005376.  [Abstract]
Denes AS, Kanca O, Affolter M (2015) A cellular process that includes asymmetric cytokinesis remodels the dorsal tracheal branches in Drosophila larvae. Development 142:1794-1805.  [Abstract]
Bieli D, Kanca O, Gohl D, Denes A, Schedl P, Affolter M, Müller M (2015) The Drosophila melanogaster mutants apblot and apXasta affect an essential apterous wing enhancer. G3 5:1129-1143.  [Abstract]
Kanca O, Ochoa-Espinosa A, Affolter M (2014) IV. Tools and methods for studying cell migration and cell rearrangement in tissue and organ development. Methods 68:228-232.  [Abstract]
Kanca O, Caussinus E, Denes AS, Percival-Smith A, Affolter M (2014) Raeppli: a whole-tissue labeling tool for live imaging of Drosophila development. Development 141:472-480.  [Abstract]
Caussinus E, Kanca O, Affolter M (2013) Protein knockouts in living eukaryotes using deGradFP and green fluorescent protein fusion targets. Current Protocols in Protein Science 73:Unit 30.2.  [Abstract]
Caussinus E, Kanca O, Affolter M (2011) Fluorescent fusion protein knockout mediated by anti-GFP nanobody. Nature Structural and Molecular Biology 19:117-121.  [Abstract]
Mitchell JS, Kanca O, McIntyre BW (2002) Lipid microdomain clustering induces a redistribution of antigen recognition and adhesion molecules on human T lymphocytes. Journal of Immunology 168:2737-2744.  [Abstract]