Bellen Lab

Oguz Kanca

Oguz Kanca

BS, Bilkent University, Ankara, Turkey
PhD, EMBL Heidelberg (Pernille Rørth)
Postdoc, Biozentrum, University of Basel (Markus Affolter)

Research Interests

Whole exome sequencing and personalized medicine prompted the need for efficient methods to test the functionality of gene variants. I am interested in establishing techniques and tools to expedite the analysis of functionality of human gene variants, using the power of Drosophila genetics.


Marcogliese PC*, Deal SL*, Andrews J*, Harnish JM*, Bhavana VH, Graves HK, Jangam S, Luo X, Liu N, Bei D, Chao YH, Hull B, Lee PT, Pan H, Longley CM, Chao HT, Chung H, Haelterman NA, Kanca O, Manivannan SN, Rossetti LZ, Gerard A, Schwaibold EMC, Guerrini R, Vetro A, England E, Murali CN, Barakat TS, van Dooren MF, Wilke M, van Slegtenhorst M, Lesca G, Sabatier I, Chatron N, Brownstein CA, Madden JA, Agrawal PB, Keller R, Pavinato L, Brusco A, Rosenfeld JA, Marom R, Wangler MF, Yamamoto S (2021) Drosophila functional screening of de novo variants in autism uncovers deleterious variants and facilitates discovery of rare neurodevelopmental diseases. bioRxiv 424813: *Contributed equally. Download PDF.   
Goodman LD, Cope H, Nil Z, Ravenscroft TA, Charng WL, Lu S, Kanca O, Tien AC, Moulton MJ, Dutta D, Pfundt R, Koolen DA, Haaxma CA, Veenstra-Knol HE, Wassink-Ruiter JSK, Wevers MR, Jones M, Walsh LE, Klee VH, Theunis M, Legius E, Steel D, Barwick KES, Kurian MA, Mohammad SS, Dale RC, Terhal PA, Kirmse B, Robinette B, Cogne B, Isidor B, Grebe TA, Kulch P, Hainline BE, Sapp K, Morava E, Klee EW, Macke EL, Trapane P, Spencer C, Undiagnosed Diseases Network (UDN), Wangler MF, Yamamoto S, Bellen HJ, Tan QKG  (2021) De novo TNPO2 variants are associated with developmental delays, dysmorphic features and neurological phenotypes in humans and alter TNPO2 activity in DrosophilaAmerican Journal of Human Genetics :submitted.   
Dutta D, Briere LC, Kanca O, Marcogliese PC, Walker MA, High FA, Vanderver A, Krier J, Carmichael N, Callahan C, Taft RJ, Simons C, Helman G, Undiagnosed Diseases Network, Wangler MF, Yamamoto S, Sweetser DA, Bellen HJ (2020)  De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment. Human Molecular Genetics 29(9):1568-1579.  [Abstract]
Bosch JA, Knight S, Kanca O, Zirin J, Yang-Zhou D, Hu Y, Rodiger J, Amador G, Bellen HJ, Perrimon N, Mohr SE (2020) Use of the CRISPR-Cas9 system in Drosophila cultured cells to introduce fluorescent tags into endogenous genes. Current Protocols in Molecular Biology 130:e112.  [Abstract]
Kanca O, Zirin J, Garcia-Marques J, Knight SM, Yang-Zhou D, Amador G, Chung HL, Zuo Z, Ma L, He Y, Lin WW, Fang Y, Ge M, Yamamoto S, Schulze KL, Hu Y, Spradling AC, Mohr SE, Perrimon N, Bellen HJ (2019) An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms. eLife 8:e51539.  [Abstract]
Kanca O, Bellen HJ (2019) La CaSSA da Drosophila: a versatile expansion of the tool box. Neuron 23:177-179.  [Abstract]
Kanca O, Andrews JC, Lee PT, Patel C, Braddock SR, Slavotinek AM, Cohen JS, Gubbels CS, Aldinger KA, Williams J, Indaram M, Fatemi A, Yu TW, Agrawal PB, Vezina G, Simons C, Crawford J, Lau CC; Undiagnosed Diseases Network, Chung WK, Markello TC, Dobyns WB, Adams DR, Gahl WA, Wangler MF, Yamamoto S, Bellen HJ, Malicdan MCV (2019) De novo variants in WDR37 are associated with epilepsy, colobomas, dysmorphism, developmental delay, intellectual disability, and cerebellar hypoplasia. American Journal of Human Genetics :Epub ahead of print.  [Abstract]
Li-Kroeger D*, Kanca O*, Lee PT, Cowan S, Lee MT, Jaiswal M, Salazar JL, He Y, Zuo Z, Bellen HJ (2018) An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in DrosophilaeLife 7:e38709. (*equal contribution) [Abstract]
Marcogliese PC, Shashi V, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Martínez-Agosto JA, Herzog M, Chen AH, Dickson PI, Lin HJ, Vera MU, Salamon N, Graham JM Jr, Ortiz D, Infante E, Steyaert W, Dermaut B, Poppe B, Chung HL, Zuo Z, Lee PT, Kanca O, Xia F, Yang Y, Smith EC, Jasien J, Kansagra S, Spiridigliozzi G, El-Dairi M, Lark R, Riley K, Koeberl DD, Golden-Grant K, Program for Undiagnosed Diseases (UD-PrOZA), Undiagnosed Diseases Network, Yamamoto S, Wangler MF, Mirzaa G, Hemelsoet D, Lee B, Nelson SF, Goldstein DB, Bellen HJ, Pena LDM (2018) IRF2BPL is associated with neurological phenotypes. American Journal of Human Genetics 103:245-260.  [Abstract]
Lee PT, Zirin J, Kanca O, Lin WW, Schulze KL, Li-Kroeger D, Tao R, Devereaux C, Hu Y, Chung V, Fang Y, He Y, Pan H, Ge M, Zuo Z, Housden BE, Mohr SE, Yamamoto S, Levis RW, Spradling AC, Perrimon N, Bellen HJ (2018) A gene-specific T2A-GAL4 library for DrosophilaeLife 7:e35574.  [Abstract]
Kanca O, Bellen HJ, Schnorrer F (2017) Gene tagging strategies to assess protein expression, localization, and function in Drosophila. Genetics 207:389-412.  [Abstract]
Bieli D, Kanca O, Requena D, Hamaratoglu F, Gohl D, Schedl P, Affolter M, Slattery M, Müller M, Estella C (2015) Establishment of a developmental compartment requires interactions between three synergistic cis-regulatory modules. PLoS Genetics 11:e1005376.  [Abstract]
Denes AS, Kanca O, Affolter M (2015) A cellular process that includes asymmetric cytokinesis remodels the dorsal tracheal branches in Drosophila larvae. Development 142:1794-1805.  [Abstract]
Bieli D, Kanca O, Gohl D, Denes A, Schedl P, Affolter M, Müller M (2015) The Drosophila melanogaster mutants apblot and apXasta affect an essential apterous wing enhancer. G3 5:1129-1143.  [Abstract]
Kanca O, Ochoa-Espinosa A, Affolter M (2014) IV. Tools and methods for studying cell migration and cell rearrangement in tissue and organ development. Methods 68:228-232.  [Abstract]
Kanca O, Caussinus E, Denes AS, Percival-Smith A, Affolter M (2014) Raeppli: a whole-tissue labeling tool for live imaging of Drosophila development. Development 141:472-480.  [Abstract]
Caussinus E, Kanca O, Affolter M (2013) Protein knockouts in living eukaryotes using deGradFP and green fluorescent protein fusion targets. Current Protocols in Protein Science 73:Unit 30.2.  [Abstract]
Caussinus E, Kanca O, Affolter M (2011) Fluorescent fusion protein knockout mediated by anti-GFP nanobody. Nature Structural and Molecular Biology 19:117-121.  [Abstract]
Mitchell JS, Kanca O, McIntyre BW (2002) Lipid microdomain clustering induces a redistribution of antigen recognition and adhesion molecules on human T lymphocytes. Journal of Immunology 168:2737-2744.  [Abstract]

Last Modified 3-31-21 by Jodie Hebert

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