Nichole Link

Nichole Link

Research Interests

Nuclear architecture and three-dimensional genome organization are important for maintaining proper gene regulation during development and differentiation. I am interested in the mechanisms that establish chromatin organization within the nucleus and how disruption of nuclear structure results in neuronal disorders.


Shah PS*, Link N*, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ (2018) Comparative flavivirus-host protein interaction mapping reveals mechanisms of dengue and Zika virus pathogenesis. Cell 175:1931-1945. (*equal contribution) [Abstract]
Malmanche N, Dourlen P, Gistelinck M, Demiautte F, Link N, Dupont C, Vanden Broeck L, Werkmeister E, Amouyel P, Bongiovanni A, Bauderlique H, Moechars D, Royou A, Bellen HJ, Lafont F, Callaerts P, Lambert JC, Dermaut B (2017) Developmental expression of 4-repeat-Tau induces neuronal aneuploidy in Drosophila tauopathy models. Scientific Reports 7:40764.  [Abstract]
Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S, Vissers LE, de Ligt J, Jhangiani SN, Xie Y, Tsang SH, Parman Y, Sivaci M, Battaloglu E, Muzny D, Wan YW, Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Link N, Schulze KL, Boerwinkle E, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler MF, Bellen HJ (2014) A Drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell 159:200-214.  [Abstract]
Link N, Abrams JM (2014) DNA loops specify p53 network responses. Cell Cycle 13:1659.  [Abstract]
Link N, Kurtz P, O'Neal M, Garcia-Hughes G, Abrams JM (2013) A p53 enhancer region regulates target genes through chromatin conformations in cis and in transGenes and Development 27:2433-2438.  [Abstract]
Chew SK, Chen P, Link N, Galindo KA, Pogue K, Abrams JM (2009) Genome-wide silencing in Drosophila captures conserved apoptotic effectors. Nature 460:123-127.  [Abstract]
Link N, Chen P, Lu WJ, Pogue K, Chuong A, Mata M, Checketts J, Abrams JM (2007) A collective form of cell death requires homeodomain interacting protein kinase. Journal of Cell Biology 178:567-574.  [Abstract]