Bellen Lab

Nichole Link

Nichole Link

BA, Hendrix College
PhD, UT Southwestern Medical Center (John Abrams)

Research Interests

My research uses Drosophila to study microcephaly and neurodevelopmental disorders caused by genetic variation and environmental pathogens. Characterization of genes associated with human diseases allows us to identify new players in well-established signaling pathways and improve our understanding of normal development.


Publications

Link N and Bellen HJ (2020) Human genetics drives basic discoveries in model organisms which in turn impacts our understanding of disease. Development :submitted.   
Link N, Bellen HJ (2020) Using Drosophila to drive the diagnosis and understand the mechanisms of rare human diseases. Development 147(21):dev191411.  [Abstract]
Link N, Chung H, Jolly A, Withers M, Tepe B, Arenkiel BR, Shah PS, Krogan NJ, Aydin H, Geckinli BB, Tos T, Isikay S, Tuysuz B, Mochida GH, Thomas AX, Clark RD, Mirzaa GM, Lupski JR, Bellen HJ (2019) Mutations in ANKLE2, a ZIKA virus target, disrupt an asymmetric cell division pathway in Drosophila neuroblasts to cause microcephaly. Developmental Cell 51:713-729.  [Abstract]
Kurtz P, Jones AE, Tiwari B, Link N, Wylie A, Tracy C, Kramer H and Abrams JM (2019) p53 directs nonapoptotic programs in postmitotic tissue. Molecular Biology of the Cell 30(11):1339-1351.  [Abstract]
Shah PS*, Link N*, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ (2018) Comparative flavivirus-host protein interaction mapping reveals mechanisms of dengue and Zika virus pathogenesis. Cell 175:1931-1945. (*equal contribution) [Abstract]
Malmanche N, Dourlen P, Gistelinck M, Demiautte F, Link N, Dupont C, Vanden Broeck L, Werkmeister E, Amouyel P, Bongiovanni A, Bauderlique H, Moechars D, Royou A, Bellen HJ, Lafont F, Callaerts P, Lambert JC, Dermaut B (2017) Developmental expression of 4-repeat-Tau induces neuronal aneuploidy in Drosophila tauopathy models. Scientific Reports 7:40764.  [Abstract]
Ziraldo R, Link N, Abrams JM and Ma L  (2015) owards automatic image analysis and assessment of the multicellular apoptosis process. IET Image Processing 9(5):424-433.  [Abstract]
Garcia-Hughes G, Link N, Ghosh AB and Abrams JM  (2015) Hid arbitrates collective cell death in the Drosophila wing. Mechanisms of Development 138(3):349-355.  [Abstract]
Jiang D, LaGory EL, Kenzelmann Broz D, Bieging KT, Brady CA, Link N, Abrams JM, Giaccia AJ and Attardi LD  (2015) Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function. Cell Reports 10(7):1096-1109.  [Abstract]
Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S, Vissers LE, de Ligt J, Jhangiani SN, Xie Y, Tsang SH, Parman Y, Sivaci M, Battaloglu E, Muzny D, Wan YW, Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Link N, Schulze KL, Boerwinkle E, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler MF, Bellen HJ (2014) A Drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell 159:200-214.  [Abstract]
Link N, Abrams JM (2014) DNA loops specify p53 network responses. Cell Cycle 13:1659.  [Abstract]
Link N, Kurtz P, O'Neal M, Garcia-Hughes G, Abrams JM (2013) A p53 enhancer region regulates target genes through chromatin conformations in cis and in transGenes and Development 27:2433-2438.  [Abstract]
Chew SK, Chen P, Link N, Galindo KA, Pogue K, Abrams JM (2009) Genome-wide silencing in Drosophila captures conserved apoptotic effectors. Nature 460:123-127.  [Abstract]
Link N, Chen P, Lu WJ, Pogue K, Chuong A, Mata M, Checketts J, Abrams JM (2007) A collective form of cell death requires homeodomain interacting protein kinase. Journal of Cell Biology 178:567-574.  [Abstract]

Last Modified 3-31-21 by Jodie Hebert

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