Mumine Senturk

Mumine Senturk

Contact Information

Tel: 832-824-8750

Research Interests

Neurodegenerative diseases are characterized by an age-dependent, progressive disruption in neuronal structures and/or neuronal function, which ultimately results in death of neuronal cells. The molecular and cellular basis of most neurodegenerative diseases remain unclear. In addition, there are no effective therapies. Hence, the main goal of our studies is to better understand the pathogenesis of neurodegenerative disorders.

Alzheimer's Disease (AD) is one of the most common neurodegenerative diseases. For years, the prevailing hypothesis of AD pathogenesis has been the amyloid cascade hypothesis, which relies on the aberrant accumulation of amyloid-β (Aβ) and the formation of Aβ plaques. Another hypothesis is based on the formation of neurofibrillary tangles, which involves the abnormal function of tau, a microtubule associated protein. However, many questions still remain with regard to how exactly Aβ and tau cause neuronal damage.

Mitochondria are critical for neuronal function and maintenance, and mitochondrial dysfunction is tightly related with several neurodegenerative diseases including AD. We hypothesize that proteins implicated in AD disrupt the function of mitochondria leading to neurodegeneration. I am currently working on the role of mitochondrial dysfunction in AD.