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Matthew Moulton

Matthew Moulton



Research Interests

Research into Alzheimer's disease (AD) has led to the identification of key molecular players in the etiology and pathogenesis of the disease. However, despite tremendous efforts, few effective therapeutic options are available for AD patients. In an effort to better understand the molecular underpinnings of AD, I seek to better understand basic biological processes that are aberrant in AD patients. Endocytosis is one such process that is is critical for the clearance of molecules that aggregate and cause the neurodegenerative pathogenesis observed in AD, including Aβ42, a protein fragment produced by cleavage of APP. Aβ42 is highly hydrophobic and is thought to be endocytosed through interactions with the lipid transporter, Apolipoprotein E (ApoE). Aβ42 may be incorporated into lipid droplets (LD) in glia which are thought to serve a neuroprotective function by sequestering peroxidated lipids and protecting neurons from reactive oxygen species. While inadequate uptake and degradation of Aβ42 in AD patients leads to protein aggregation and plaque formation, it is unclear the precise role LDs play in Aβ42 sequestration. I am interested in identifying the key molecular components responsible for normal endocytic uptake, sequestration, and degradation of Aβ42 in neurons and glia in an effort to identify new therapeutic targets for AD.


Publications

Xie Y, Kaufmann D, Moulton MJ, Panahi S, Gaynes JA, Watters HN, Zhou D, Xue HH, Fung CM, Levine EM, Letsou A, Brennan KC, Dorsky RI (2016) Lef1-dependent hypothalamic neurogenesis inhibits anxiety. PLoS Biol 15:e2002257.  [Abstract]
Moulton MJ, Letsou A (2016) Modeling congenital disease and inborn errors of development in Drosophila melanogasterDisease Models & Mechanisms 9:253-269.  [Abstract]
Robertson JA, Ślipiński A, Moulton MJ, Shockley FW, Giorgi A, Lord NP, McKenna DD, Tomaszewska W, Forrester J, Miller KB, Whiting MF, McHugh JV (2015) Phylogeny and classification of Cucujoidea and the recognition of a new superfamily Coccinelloidea (Coleoptera: Cucujiformia)Systematic Entomology 40:745-778.   
Cline AR, Smith TR, Miller KB, Moulton MJ, Whiting MF, Audisio P (2014) Molecular phylogeny of Nitidulidae: assessment of subfamilial and tribal classification and formalization of the family Cybocephalidae (Coleoptera: Cucujoidea)Systematic Entomology 39:758-772.   
Song H, Moulton MJ, Whiting MF (2014) Rampant nuclear insertion of mtDNA across diverse lineages within Orthoptera (Insecta)PLoS One 9:e110508.  [Abstract]
Song H, Moulton MJ, Hiatt KD, Whiting MF (2013) Uncovering historical signature of mitochondrial DNA hidden in the nuclear genome: The biogeography of Schistocerca revisited. Cladistics 29:643-662.   
Moulton MJ, Song H, Whiting MF (2010) Assessing the effects of primer specificity on eliminating numt coamplification in DNA barcoding: a case study from Orthoptera (Arthropoda: Insecta)Molecular Ecology Resources 10:615-627.  [Abstract]