Lita Duraine

Lita Duraine


Contact Information

Tel: (832) 824-8704
Email: duraine@bcm.edu


Research Interests

My interests revolve around Electron Microscopy and the support of our researchers, post docs, graduate students, and other collaborators. I help everyone with their samples from dissection, tissue processing and embedding, sectioning and TEM examination. I have had the opportunity to work on a wide diversity of specimens in my career from plants, mammals, fish, reptiles, and now insects. Manipulating Drosophila melanogaster is a bit challenging from an EM point of view, but is so indispensible for genomic research in Amyotrophic lateral sclerosis (ALS), Alzheimer's, and other debilitating diseases. My curriculum includes University of the Pacific Pre-Pharmacy program and San Joaquin Delta Microscopy Technology Center. I have set up microscopy labs for both NASA Ames Research Center in California, and for Boston Scientific/ Target Therapeutics. My experience includes Transmission and Scanning Electron Microscopy, and Energy Dispersive Spectrometry, for both biological and materials microscopy.


Publications

Chen K, Lin G, Haelterman NA, Ho TS, Li T, Li Z, Duraine L, Graham BH, Jaiswal M, Yamamoto S, Rasband MN, Bellen HJ (2016) Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. eLife 5:e16043.  [Abstract]
David-Morrison G, Xu Z, Rui YN, Charng WL, Jaiswal M, Yamamoto S, Xiong B, Zhang K, Sandoval H, Duraine L, Zuo Z, Zhang S, Bellen HJ (2016) WAC regulates mTOR activity by acting as an adaptor for the TTT and Pontin/Reptin complexes. Developmental Cell 36:139-151.  [Abstract]
Tian X, Gala U, Zhang Y, Shang W, Nagarkar Jaiswal S, di Ronza A, Jaiswal M, Yamamoto S, Sandoval H, Duraine L, Sardiello M, Sillitoe RV, Venkatachalam K, Fan H, Bellen HJ, Tong C (2015) A voltage gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biology 13:e1002103.  [Abstract]
Wong CO, Chen K, Lin YQ, Chao Y, Duraine L, Lu Z, Yoon WH, Sullivan JM, Broadhead GT, Sumner CJ, Lloyd TE, Macleod GT, Bellen HJ, Venkatachalam K (2014) A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission. Neuron 84:764-777.  [Abstract]
Sandoval H, Yao CK, Chen K, Jaiswal M, Donti T, Lin YQ, Bayat V, Xiong B,Zhang K, David G, Charng WL, Yamamoto S, Duraine L, Graham BH, Bellen HJ (2014) Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production. eLife 3:e03558.  [Abstract]
Halstead JM, Lin YQ, Duraine L, Hamilton RS, Ball G, Neely GG, Bellen HJ, Davis I (2014) Syncrip/hnRNP Q influences synaptic transmission and regulates BMP signaling at the Drosophila neuromuscular synapse. Biology Open 3:839-849.  [Abstract]
Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ (2014) The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biology 12:e1001847.  [Abstract]
Xiong B, Bayat V, Jaiswal M, Zhang K, Sandoval H, Charng W-L, Li T, David G, Duraine L, Lin YQ, Neely GG, Yamamoto S, Bellen HJ (2012) Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells. PLoS Biology 10:e1001438.  [Abstract]
Chen YC, Lin YQ, Banerjee S, Venken K, Li J, Ismat A, Chen K, Duraine L, Bellen HJ, Bhat MA (2012) Drosophila Neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission. Journal of Neuroscience 32:16018-16030.  [Abstract]