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Liping Wang

Liping Wang



Research Interests

The role of sphingolipid metabolism and endolysosomal dysfunction in neurodegenerative diseases, including Parkinson's disease (PD), is not well understood. My research is focused on the mitochondrial protein Pink1, retromer components Vps26, Vps29, and Vps35, and phospholipase PLA2G6, which are all implicated in PD or Parkinsonism. By utilizing genetic recombinase and the T2A-Gal4 system, I seek to understand sphingolipid metabolism alterations induced by loss of each of these genes. By understanding sphingolipid metabolism alterations in PD-associated mutants, I hope to discover novel pathogenic pathways of PD.


Publications

Geng J*, Wang L*, Lee JY, Chen CK, Chang KT (2016) Phosphorylation of synaptojanin differentially regulates endocytosis of functionally distinct synaptic vesicle pools. Journal of Neuroscience 36:8882-8894. (*equal contribution) [Abstract]