Bellen Lab

Lindsey Goodman

Lindsey Goodman

BS, University of Texas at Austin (Human Biology: Genetics and Biotechnology)
BS, University of Texas at Austin (Neurobiology)
PhD, University of Pennsylvania, Philadelphia, PA (Nancy Bonini)

Research Interests

I am interested in mechanisms underlying neurodegenerative diseases in juveniles and in an aging population. Drosophila is an ideal model system to test potential disease genes and to define degenerative effects in a tissue-specific manner. My research focuses on defining cellular/molecular mechanisms underlying these effects. Drugs targeting defined pathways can further be tested in Drosophila, aiding in the development of potential therapies for patients.


Publications

Goodman LD, Prudencio M, Kramer NJ, Martinez-Ramirez LF, Srinivasan AR, Lan M, Parisi MJ, Zhu Y, Chew J, Cook CN, Berson A, Gitler AD, Petrucelli L, Bonini NM (2019) Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD. Nature Neuroscience 22:863-874.  [Abstract]
Berson A*, Goodman LD*, Sartoris AN, Otte CG, Aykit JA, Lee VM, Trojanowski JQ, Bonini NM (2019) Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies. Acta Neuropathologica Communications 7:65. (*equal contribution) [Abstract]
Goodman LD, Prudencio M, Srinivasan AR, Rifai OM, Lee VM, Petrucelli L, Bonini NM (2019) eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS . Acta Neuropathologica Communications 7:62.  [Abstract]
Yuan AL, Ricks CB, Bohm AK, Lun X, Maxwell L, Safdar S, Bukhari S, Gerber A, Sayeed W, Bering EA, Pedersen H, Chan JA, Shen Y, Marra M, Kaplan DR, Mason W, Goodman LD, Ezhilarasan R, Kaufmann AB, Cabral M, Robbins SM, Senger DL, Cahill DP, Sulman EP, Cairncross JG, Blough MD (2018) ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts. PLoS One 13:e0202860.  [Abstract]
Mordes DA, Prudencio M*, Goodman LD*, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K (2018) Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathologica Communications 6:55. (*equal contribution) [Abstract]
Olar A, Goodman LD, Wani KM, Boehling NS, Sharma DS, Mody RR, Gumin J, Claus EB, Lang FF, Cloughesy TF, Lai A, Aldape KD, DeMonte F, Sulman EP (2018) A gene expression signature predicts recurrence-free survival in meningioma. Oncotarget 9:16087-16098.  [Abstract]
Shahar T, Rozovski U, Hess KR, Hossain A, Gumin J, Gao F, Fuller GN, Goodman L, Sulman EP, Lang FF (2017) Percentage of mesenchymal stem cells in high-grade glioma tumor samples correlates with patient survival. Neuro-Oncology 19:660-668.  [Abstract]
Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW 3rd, Goodman LD, Daughrity L, Chew J, Garrett A, Pregent L, Jansen-West K, Tabassian LJ, Rademakers R, Boylan K, Graff-Radford NR, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Deng N, Feng Y, Cheng TH, Dickson DW, Cohen SN, Bonini NM, Link CD, Gao FB, Petrucelli L, Gitler AD (2016) Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts. Science 353:708-712.  [Abstract]
Yu Z, Goodman LD, Shieh SY, Min M, Teng X, Zhu Y, Bonini NM (2015) A fly model for the CCUG-repeat expansion of myotonic dystrophy type 2 reveals a novel interaction with MBNL1. Human Molecular Genetics 24:954-962.  [Abstract]
Bhat KPL, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S, Long L, Lelic N, Wang S, Gumin J, Raj D, Kodama Y, Raghunathan A, Olar A, Joshi K, Pelloski CE, Heimberger A, Kim SH, Cahill DP, Rao G, Den Dunnen WFA, Boddeke HWGM, Phillips HS, Nakano I, Lang FF, Colman H, Sulman EP, Aldape K (2013) Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma. Cancer Cell 24:331-346.  [Abstract]

Bellen Lab
1250 Moursund St., Suite N1125 - Houston, TX 77030

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