Karen Schulze

Karen Schulze

Contact Information

Tel: (832) 824-8757
Email: kschulze@bcm.edu

Research Interests


Nagarkar-Jaiswal S, Lee PT, Campbell ME, Chen K, Anguiano-Zarate S, Cantu Gutierrez M, Busby T, Lin WW, He Y, Schulze KL, Booth BW, Evans-Holm M, Venken KJ, Levis RW, Spradling AC, Hoskins RA, Bellen HJ (2015) A library of MiMICs allows tagging of genes and reversible spatial and temporal knockdown of proteins in Drosophila. eLife 4:e05338.  [Abstract]
Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S, Vissers LE, de Ligt J, Jhangiani SN, Xie Y, Tsang SH, Parman Y, Sivaci M, Battaloglu E, Muzny D, Wan YW, Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Link N, Schulze KL, Boerwinkle E, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler MF, Bellen HJ (2014) A Drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell 159:200-214.  [Abstract]
Yamamoto S, Schulze KL, Bellen HJ (2014) Introduction to Notch signaling. Methods in Molecular Biology 1187:1-14.  [Abstract]
Winther AM, Jiao W, Vorontsova O, Rees KA, Koh TW, Sopova E, Schulze KL, Bellen HJ, Shupliakov O (2012) The dynamin-binding domains of Dap160/Intersectin affect bulk membrane retrieval in synapses. Journal of Cell Science 126:1021-1031.  [Abstract]
Giagtzoglou N, Yamamoto S, Zitserman D, Graves HK, Schulze KL, Wang H, Klein H, Roegiers F, Bellen HJ (2012) dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions. Journal of Cell Biology 196:65-83.  [Abstract]
Venken KJT, Schulze KL, Haelterman NA, Pan H, He Y, Evans-Holm M, Carlson JW, Levis RW, Spradling AC, Hoskins RA, Bellen HJ (2011) MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Nature Methods 8:737-743.  [Abstract]
Bellen HJ, Levis RW, He Y, Carlson JW, Evans-Holm M, Bae E, Kim J, Metaxakis A, Savakis C, Schulze KL, Hoskins RA, Spradling AC (2011) The Drosophila Gene Disruption Project: progress using transposons with distinctive site-specificities. Genetics 188:731-743.  [Abstract]
Venken KJT, Popodi E, Holtzman SL, Schulze KL, Park S, Carlson JW, Hoskins RA, Bellen HJ, Kaufman TC (2010) A molecularly defined duplication set for the X chromosome of Drosophila melanogasterGenetics 186:1111-1125.  [Abstract]
Patel PH, Costa-Mattioli M, Schulze KL, Bellen HJ (2009) The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. Journal of Cell Biology 185:1181-1194.  [Abstract]
Rajan A, Tien AC, Haueter CM, Schulze KL, Bellen HJ (2009) The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nature Cell Biology 11:815-824.  [Abstract]
Venken, KJT, Carlson JW, Schulze KL, Pan H, He Y, Spokony R, Wan KH, Koriabine M, de Jong PJ, White KP, Bellen HJ, Hoskins RA (2009) Versatile P[acman] BAC Libraries for transgenesis studies in Drosophila melanogasterNature Methods 6:431-434.  [Abstract]
Andrews HK, Giagtzoglou N, Yamamoto S, Schulze KL, Bellen HJ (2009) Sequoia regulates cell fate decisions in developing adult Drosophila external sensory organs. EMBO Reports 10:636-641.  [Abstract]
Tien AC, Rajan A, Schulze KL, Ryoo HD, Acar M, Steller H, Bellen HJ (2008) Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogasterJournal of Cell Biology 182:1113-1125.  [Abstract]
Ohyama T, Verstreken P, Ly CV, Rosenmund T, Rajan A, Tien AC, Haueter C, Schulze KL, Bellen HJ (2007) Huntingtin interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles. Journal of Cell Biology 179:1481-1496.  [Abstract]
Halachmi N, Schulze KL, Inbal A, Salzberg A (2007) Additional sex combs affects antennal development by means of spatially restricted repression of Antp and wgDevelopmental Dynamics 236:2118-2130.  [Abstract]
Zhang J, Schulze KL, Hiesinger PR, Suyama K, Wang S, Fish M, Acar M, Hoskins RA, Bellen HJ, Scott MP (2007) Thirty-one flavors of Drosophila Rab proteins. Genetics 176:1307-1322.  [Abstract]
Zhai RG, Cao Y, Hiesinger PR, Zhou Y, Mehta SQ, Schulze KL, Verstreken P, Bellen HJ (2006) Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. PLoS Biology 4:e416.  [Abstract]
Hiesinger PR, Zhai RG, Zhou Y, Koh TW, Mehta SQ, Schulze KL, Cao Y, Verstreken P, Clandinin TR, Fischbach KF, Meinertzhagen IA, Bellen HJ (2006) Activity-independent prespecification of synaptic partners in the visual map of Drosophila. Current Biology 16:1835-1843.  [Abstract]
Hiesinger PR, Fayyazuddin A, Mehta SQ, Rosenmund T, Schulze KL, Zhai RG, Verstreken P, Cao Y, Zhou Y, Kunz J, Bellen HJ (2005) The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell 121:607-620.  [Abstract]
Mehta SQ, Hiesinger PR, Beronja S, Zhai RG, Schulze KL, Verstreken P, Cao Y, Zhou Y, Tepass U, Crair MC, Bellen HJ (2005) Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron 46:219-232.  [Abstract]
Escudero LM, Caminero E, Schulze KL, Bellen HJ, Modolell J (2005) Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila. Development 132:1211-1222.  [Abstract]
Bellen HJ, Schulze KL (2004) Invertebrate Glia. Myelin Biology and Disorders 1:199-222.   
Bellen HJ, Levis RW, Liao G, He Y, Carlson JW, Tsang G, Evans-Holm M, Hiesinger PR, Schulze KL, Rubin GM, Hoskins RA, Spradling AC (2004) The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics 167:761-781.  [Abstract]
Verstreken P, Koh TW, Schulze KL, Zhai RG, Hiesinger PR, Zhou Y, Mehta SQ, Cao Y, Roos J, Bellen HJ (2003) Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating. Neuron 40:733-748.  [Abstract]
Zhai RG, Hiesinger PR, Koh TW, Verstreken P, Schulze KL, Cao Y, Jafar-Nejad H, Norga KK, Pan H, Bayat V, Greenbaum MP, Bellen HJ (2003) Mapping Drosophila mutations with molecularly defined P element insertions. Proceedings of the National Academy of Sciences USA 100:10860-10865.  [Abstract]
Chen S, Zheng X, Schulze KL, Morris T, Bellen H, Stanley EF (2002) Enhancement of presynaptic calcium current by cysteine string protein. Journal of Physiology 538:383-389.  [Abstract]
Fergestad T, Wu MN, Schulze KL, Lloyd TE, Bellen HJ, Broadie K (2001) Targeted mutations in the syntaxin H3 domain specifically disrupt SNARE complex function in synaptic transmission. Journal of Neuroscience 21:9142-9150.  [Abstract]
Wu MN, Schulze KL, Lloyd TE, Bellen HJ (2001) The ROP-syntaxin interaction inhibits neurotransmitter release. European Journal of Cell Biology 80:196-199.  [Abstract]
Schulze KL, Bellen HJ (1996) Drosophila syntaxin is required for cell viability and may function in membrane formation and stabilization. Genetics 144:1713-1724.  [Abstract]
Schulze KL, Broadie K, Perin MS, Bellen HJ (1995) Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission. Cell 80:311-320.  [Abstract]
Broadie K, Prokop A, Bellen HJ, O'Kane CJ, Schulze KL, Sweeney ST (1995) Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila. Neuron 15:663-673.  [Abstract]
Salzberg A, D'Evelyn D, Schulze KL, Lee JK, Strumpf D, Tsai L, Bellen HJ (1994) Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13:269-287.  [Abstract]
Schulze KL*, Littleton JT*, Salzberg A, Halachmi N, Stern M, Lev Z, Bellen HJ (1994) rop, a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo. Neuron 13:1099-1108. (*equal contribution) [Abstract]
Lopes JM, Schulze KL, Yates JW, Hirsch JP, Henry SA (1993) The INO1 promoter of Saccharomyces cerevisiae includes an upstream repressor sequence (URS1) common to a diverse set of yeast genes. Journal of Bacteriology 175:4235-4238.  [Abstract]
Lopes JM, Hirsch JP, Chorgo PA, Schulze KL, Henry SA (1991) Analysis of sequences in the INO1 promoter that are involved in its regulation by phospholipid precursors. Nucleic Acids Research 19:1687-1693.  [Abstract]