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Julia Wang

Julia Wang



Research Interests

I am interested in combining patient genomic data with Drosophila genetics to understand fundamental biological processes.

The etiology of rare diseases is often unknown. Although sequencing data from these patients yield candidate genes, we often lack functional validation. Drosophila and its powerful genetic tools can efficiently validate the disease-causing genetic variants and allow us to pursue the underlying mechanisms of disease.

My project involves taking novel candidate disease causing genes from patients and determining pathogenic variants in Drosophila. Furthermore, because many of these candidates lack functional annotation, I hope to dissect their roles in basic biological mechanisms.


Publications

Wang J*, Al-Ouran R*, Hu Y*, Kim SY*, Wan YW, Wangler MF, Yamamoto S, Chao HT, UDN Consortium, Comjean A, Mohr SE, Perrimon N, Liu Z, Bellen HJ (2017) MARRVEL: integration of human and model organism genetic resources to facilitate functional annotation of the human genome. American Journal of Human Genetics 100:843-853. (*equal contribution) [Abstract]
Wang J, Wang H, Guo C, Luo W, Lawler A, Reddy A, Wang J, Sun EB, Eitzman DT (2014) Mebendazole reduces vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice. PLoS One 9:e90146.  [Abstract]
Wang J, Wang H, Luo W, Guo C, Wang J, Chen YE, Chang L, Eitzman DT (2013) Leptin-induced endothelial dysfunction is mediated by sympathetic nervous system activity. Journal of the American Heart Association 2:e000299.  [Abstract]
Wang H, Luo W, Wang J, Guo C, Wolffe SL, Wang J, Sun EB, Bradley KN, Campbell AD, Eitzman DT (2013) Paradoxical protection from atherosclerosis and thrombosis in a mouse model of sickle cell disease. British Journal of Haematology 162:120-129.  [Abstract]
Luo W, Wang H, Ohman MK, Guo C, Shi K, Wang J, Eitzman DT (2012) P-selectin glycoprotein ligand-1 deficiency leads to cytokine resistance and protection against atherosclerosis in apolipoprotein E deficient mice. Atherosclerosis 220:110-117.  [Abstract]