Hyunglok Chung

Hyunglok Chung

Research Interests

I am part of the Undiagnosed Diseases Network (UDN) team, working towards unraveling the genetic and molecular basis for diseases caused by yet unknown mechanisms. As one of my projects, I am investigating the DMXL1 human gene and its variants identified by Whole-Genome Sequencing (WGS) in a UDN patient. I will determine the potential pathogenicity of DMXL1 variants found in the patient and explore the molecular functions of Rabconnectin-3a, the fly homologue.

In addition, as I am particularly interested in the genes associated with developmental signaling pathways such as Hippo (Hpo), Hedgehog (Hh) and Wingless (Wg), I will focus on the UDN cases relevant to these pathways. I am eager to discover the mechanisms by which the variants affect these developmental signaling pathways and mediate the pathogenesis of these rare human diseases.


Chung HL, Choi KW (2016) Schip1, a new upstream regulator of Hippo signaling. Cell Cycle 15:2097-2098.  [Abstract]
Chung HL, Augustine GJ, Choi KW (2016) Drosophila Schip1 links Expanded and Tao-1 to regulate Hippo signaling. Developmental Cell 36:511-524.  [Abstract]