Guang Lin

Guang Lin

Research Interests

I am interested in studying the molecular function of genes that cause neurodegenerative diseases. In collaboration with other members in the lab, my research has focused on VAPB, frataxin and PLA2G6, which cause Amyotrophic Lateral Sclerosis (ALS), Friedreich's Ataxia (FA) and Neurodegeneration with brain iron accumulations (NBIAs), respectively. We have generated Drosophila loss-of-function mutations for each of them and are currently studying the phenotypes associated with loss of these genes. By studying the molecular mechanisms that underlie the identified phenotypes, we hope to gain insight in the clinical pathology of these neurodegenerative diseases.


Lin G*, Mao D*, Bellen HJ (2017) Amyotrophic Lateral Sclerosis pathogenesis converges on defects in protein homeostasis associated with TDP-43 mislocalization and proteasome-mediated degradation overload. Current Topics in Developmental Biology 121:111-171. (*equal contribution) [Abstract]
Chen K, Ho TS, Lin G, Tan KL, Rasband MN, Bellen HJ (2016) Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals. eLife 5:e20732.  [Abstract]
Chen K, Lin G, Haelterman NA, Ho TS, Li T, Li Z, Duraine L, Graham BH, Jaiswal M, Yamamoto S, Rasband MN, Bellen HJ (2016) Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. eLife 5:e16043.  [Abstract]
Li T, Fan J, Blanco-Sánchez B, Giagtzoglou N, Lin G, Yamamoto S, Jaiswal M, Chen K, Zhang J, Wei W, Lewis MT, Groves AK, Westerfield M, Jia J, Bellen HJ (2016) Ubr3, a novel modulator of Hh signaling affects the degradation of Costal-2 and Kif7 through poly-ubiquitination. PLoS Genetics 12:e1006054.  [Abstract]
Fan G, Lin G, Lucito R, Tonks NK (2013) Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells. Journal of Biological Chemistry 288:24923-24934.  [Abstract]
Yu M, Lin G, Arshadi N, Kalatskaya I, Xue B, Haider S, Nguyen F, Boutros PC, Elson A, Muthuswamy LB, Tonks NK, Muthuswamy SK (2012) Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation. Molecular Cell 32:3913-3924.  [Abstract]
Lin G, Aranda V, Muthuswamy SK, Tonks NK (2011) Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes and Development 25:1412-1425.  [Abstract]
Lan HC, Li HJ, Lin G, Lai PY, Chung BC (2007) Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. Molecular and Cellular Biology 27:2027-2036.  [Abstract]
Sun KH, Sun GH, Tsai CY, Wang HH, Chang CI, Lin G, Lin WW, Tang SJ (2005) Expression, purification, refolding, and characterization of recombinant human soluble-Fas ligand from Escherichia coliEnzyme and Microbial Technology 36:527-534.   
Hsu HJ, Lin G, Chung BC (2003) Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1bDevelopment 130:2107-2116.  [Abstract]
Tang SJ, Sun KH, Sun GH, Lin G, Lin WW, Chuang MJ (1999) Cold-induced ependymin expression in zebrafish and carp brain: implications for cold acclimation. FEBS Letters 459:95-99.  [Abstract]