Guang Lin

Contact Information

Tel:	(832) 824-8750
Email:	guangl@bcm.edu

Research Interests

I am interested in identifying novel genes and molecular pathways that play a role in the etiology of neurological diseases. To achieve this goal, I am currently studying the Drosophila neuromuscular junction (NMJ), the site where axon terminals of motor neurons contact the muscle to control muscle contraction. Along with Kuchuan and Nele, I am performing a forward genetic screen to identify novel genes that are required for proper NMJ development and function. Here, we are analyzing NMJ morphology and synaptic transmission in mutant larvae, generated through the X-screen project. We hypothesize that loss of a gene, required for the development and/or function of the NMJ, could lead to abnormal neuronal activity and eventually neuronal loss. Hopefully, through the identification and characterization of these genes, we can extend our knowledge about NMJ and the molecular pathology of neurological diseases.

Publications

Lin G, Aranda V, Muthuswamy SK, Tonks NK (2011) Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes Dev. 25:1412-1425. [Abstract]

Lan HC, Li HJ, Lin G, Lai PY, Chung BC (2007) Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. Molecular and Cellular Biology 27:2027-2036. [Abstract]

Sun KH, Sun GH, Tsai CY, Wang HH, Chang CI, Lin G, Lin WW, Tang SJ (2005) Expression, purification, refolding, and characterization of recombinant human soluble-Fas ligand from Escherichia coli. Enzyme and Microbial Technology 36:527–534.

Hsu HJ, Lin G, Chung BC (2003) Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1b. Development 130:2107-2116. [Abstract]

Tang SJ, Sun KH, Sun GH, Lin G, Lin WW, Chuang MJ (1999) Cold-induced ependymin expression in zebrafish and carp brain: implications for cold acclimation. FEBS Letters 459:95-99. [Abstract]