Research Interests
I am interested in deciphering the process and mechanisms of neurodegeneration through the study of Drosophila mutants.
My main project in the lab is the expression of mitochondrial genome-encoded respiratory chain genes from the nucleus (allotopic expression) to rescue encephalomyopathy phenotypes arising from Drosophila mitochondrial DNA mutations.
I am also working on the complementation group, XE14, that has been isolated from our lab's mosaic screen for essential genes on the X chromosome.
XE14 eyFLP mutant clones manifest degenerative electroretinogram profiles and the presence of autophagosome-like structures in the lamina. |
Publications- Beaumont V, Thompson SA, Choudhry F, Nuthall H, Glantschnig H, Lipfert L, David GR, Swain CJ, McAllister G, Munoz-Sanjuan I (2007) Evidence for an enhancement of excitatory transmission in adult CNS by Wnt signaling pathway modulation. Molecular and Cellular Neuroscience 35:513-524. [Abstract]
- Acar M, Jafar-Nejad H, Giagtzoglou N, Yallampalli S, David G, He Y, Delidakis C, Bellen HJ (2006) Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. Development 133:1979-1989. [Abstract]
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