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Dongxue Mao

Dongxue Mao



Research Interests

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons, leading to muscle atrophy and paralysis. Mutations in VapB cause ALS, but the mechanism is unclear. I am interested in understanding the cellular functions of VapBin order to shed light on how loss of VapB can cause a motor neuron disease using Drosophila melanogaster.


Publications

Lin G*, Mao D*, Bellen HJ (2017) Amyotrophic Lateral Sclerosis pathogenesis converges on defects in protein homeostasis associated with TDP-43 mislocalization and proteasome-mediated degradation overload. Current Topics in Developmental Biology 121:111-171. (*equal contribution) [Abstract]