Bellen Lab

Dongxue Mao

Dongxue Mao

BS, Tsinghua University, China
PhD, Baylor College of Medicine (Hugo Bellen)

Research Interests

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons, leading to muscle atrophy and paralysis. Mutations in VapB cause ALS, but the mechanism is unclear. I am interested in understanding the cellular functions of VapBin order to shed light on how loss of VapB can cause a motor neuron disease using Drosophila melanogaster.


Publications

Wang J, Mao D, Fazal F, Kim SY, Yamamoto S, Bellen H, Liu Z (2019) Using MARRVEL v1.2 for bioinformatics analysis of human genes and variant pathogenicity. Current Protocols in Bioinformatics 67:e85.  [Abstract]
Şentürk M, Mao D, Bellen HJ (2019) Loss of proteins associated with amyotrophic lateral sclerosis affects lysosomal acidification via different routes. Autophagy 28:1-3.  [Abstract]
Şentürk M, Lin G, Mao D, Zuo Z, Watson E, Mikos AG, Bellen HJ (2019) Ubiquilins regulate autophagic flux through mTOR signaling and lysosomal acidification. Nature Cell Biology 21:384-396.  [Abstract]
Mao D, Lin G, Tepe B, Zuo Z, Tan KL, Senturk M, Zhang S, Arenkiel BR, Sardiello M, Bellen HJ (2019) VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway. Autophagy 11:1-20.  [Abstract]
Lin G, Lee PT, Chen K, Mao D, Tan KL, Zuo Z, Lin WW, Wang L, Bellen HJ (2018) Phospholipase PLA2G6, a Parkinsonism-associated gene, affects Vps26 and Vps35, retromer function, and ceramide levels, similar to α-Synuclein gain. Cell Metabolism 28:605-618.  [Abstract]
Lin G*, Mao D*, Bellen HJ (2017) Amyotrophic Lateral Sclerosis pathogenesis converges on defects in protein homeostasis associated with TDP-43 mislocalization and proteasome-mediated degradation overload. Current Topics in Developmental Biology 121:111-171. (*equal contribution) [Abstract]

Last Modified 3-31-21 by Jodie Hebert

top ↑