Bellen Lab

Burak Tepe

Burak Tepe

BSc, Bogazici University, Turkey
PhD, Baylor College of Medicine (Ben Arenkiel/Hugo Bellen)

Research Interests

Friedreich's ataxia (FRDA) is the most prevalent form of recessive cerebellar ataxia and it is caused by mutations in Frataxin (FXN). Frataxin (FXN) is required for normal mitochondrial function and intracellular iron homeostasis. We have recently shown a mitochondria independent pathway through iron accumulation, sphingolipid synthesis and ectopic activation of the PDK1/Mef2 signaling leading to neurodegeneration in both Drosophila and mouse models. Currently I am investigating therapeutic potential of manipulating the sphingolipid/PDK1 pathway to suppress the neurodegenerative features caused by loss of FXN.


Publications

Ravenscroft TA, Janssens J, Lee PT, Tepe B, Marcogliese PC, Makhzami S, Holmes T, Aerts S, Bellen HJ (2020) Drosophila voltage-gated sodium channels are only expressed in active neurons and are localized to distal axonal initial segment-like domains. Journal of Neuroscience 40:7999-8024.  [Abstract]
Link N, Chung HL, Jolly A, Withers M, Tepe B, Arenkiel BR, Shah PS, Krogan NJ, Aydin H, Geckinli BB, Tos T, Isikay S, Tuysuz B, Mochida GH, Thomas AX, Clark RD, Mirzaa GM, Lupski JR, Bellen HJ (2019) Mutations in ANKLE2, a ZIKA virus target, disrupt an asymmetric cell division pathway in Drosophila neuroblasts to cause microcephaly. Developmental Cell 51:713-729.  [Abstract]
Mao D, Lin G, Tepe B, Zuo Z, Tan KL, Senturk M, Zhang S, Arenkiel BR, Sardiello M, Bellen HJ (2019) VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway. Autophagy 11:1-20.  [Abstract]
Liu G, Swanson J, Pekarek B, Panneerselvam S, Ung K, Tepe B, Huang L, Arenkiel BR (2018) A combinatorial approach to circuit mapping in the mouse olfactory bulb. Extracellular Recording Approaches 134:129-142.   
Scavuzzo MA, Chmielowiec J, Yang D, Wamble K, Chaboub LS, Duraine L, Tepe B, Glasgow SM, Arenkiel BR, Brou C, Deneen B, Borowiak M (2018) Pancreatic cell fate determination relies on Notch ligand trafficking by NFIA. Cell Reports 25:3811-3827.  [Abstract]
Tepe B, Hill MC, Pekarek BT, Hunt PJ, Martin TJ, Martin JF, Arenkiel BR (2018) Single-cell RNA-seq of mouse olfactory bulb reveals cellular heterogeneity and activity-dependent molecular census of adult-born neurons. Cell Reports 25:2689-2703.  [Abstract]
Liu G, Patel JM, Tepe B, McClard CK, Swanson J, Quast KB, Arenkiel BR (2018) An objective and reproducible test of olfactory learning and discrimination in mice. Journal of Visualized Experiments: JoVE 2018 Mar 22:(133).  [Abstract]
Liu G*, McClard CK*, Tepe B*, Swanson J, Pekarek B, Panneerselvam S, Arenkiel BR (2017) Olfactory cued learning paradigm. Bio-protocol 7:e2251. (*equal contribution) [Abstract]
Herman AM, Ortiz-Guzman J, Kochukov M, Herman I, Quast KB, Patel JM, Tepe B, Carlson JC, Ung K, Selever J, Tong Q, Arenkiel BR (2016) A cholinergic basal forebrain feeding circuit modulates appetite suppression. Nature 538:253-256.  [Abstract]
Garcia I, Bhullar PK, Tepe B, Ortiz-Guzman J, Huang L, Herman AM, Chaboub L, Deneen B, Justice NJ, Arenkiel BR (2016) Local corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb. Brain Structure & Function 221:1-20.  [Abstract]

Last Modified 3-31-21 by Jodie Hebert

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