Hugo J. Bellen, D.V.M., Ph.D.

Investigator, Howard Hughes Medical Institute, Baylor College of Medicine
Professor, Departments of Molecular and Human Genetics and Neuroscience, and Program in Developmental Biology

Baylor College of Medicine
One Baylor Plaza, T628, Mailstop:BCM235
Houston, TX 77030
Tel: 713/798-5272  •  Fax: 713/798-3694  •  E-mail: hbellen@bcm.edu

Training • Appointments • Publications • Seminars • Teaching

Education

1971-1976

Commercial Engineer (Engineering & M.B.A.), Magna Cum Laude

 

University of Brussels (V.U.B.), Belgium

 
1977-1980

Preveterinary Medicine, Magna Cum Laude

 

University of Antwerp (R.U.C.A.), Belgium

 
1980-1983

Doctor in Veterinary Medicine, Magna Cum Laude

 

University of Ghent (R.U.G.), Belgium

 
1983-1986

Ph.D. in Genetics, University of California, Davis, CA

  Thesis: "Multiple effects of dunce mutations of Drosophila melanogaster and their interactions with suppressors"
  Advisor: Dr. J. A. Kiger.

Postgraduate Training

1987-1989

Postdoctoral Researcher, supported by a N.A.T.O. Fellowship

 

University of Basel, Biozentrum, Department of Cell Biology, Switzerland

  Advisor: Dr. W. J. Gehring.

Other Advanced Training

1977-1980

Research Associate in Econometrics, supported by the National Fund of Scientific Research

 

University of Antwerp (R.U.C.A.), Department of Economical Sciences, Belgium

  Advisor: Dr. C. Van Herbruggen

Academic Appointments

• Past Appointments

1989-1995

Assistant Investigator, Howard Hughes Medical Institute

1989-1994

Assistant Professor, Departments of Molecular and Human Genetics; Cell Biology; and Program in Cell and Molecular Biology

1990-1994

Assistant Professor, Division of Neuroscience

1991-1994

Assistant Professor, Program in Developmental Biology

1991-1996

Co-Director, Graduate Program in Developmental Biology

1994-1997

Associate Professor, Departments of Molecular and Human Genetics; Cell Biology; Division of Neuroscience; Programs in Cell and Molecular Biology, and Developmental Biology

1995-1999

Associate Investigator, Howard Hughes Medical Institute
1997-2009

Professor, Department of Molecular and Cellular Biology

• Current Appointments

1996-present

Director, Graduate Program in Developmental Biology

1997-present

Professor, Departments of Molecular and Human Genetics; Neuroscience; and Program in Developmental Biology

1999-present

Investigator, Howard Hughes Medical Institute

1999-present

Charles Darwin Professor in Genetics, Department of Molecular and Human Genetics

2000-present

March of Dimes Professor in Developmental Biology

2007-present

Adjunct Member, The University of Texas MD Anderson Cancer Center

2008-2013

Member, Scientific Advisory Board at the Max Planck Institute for Biophysical Chemistry in Goettingen

Professional Societies

Honors and Awards

Review Panels

Editorial Activities

toptop

Publications

• Articles Published or in Press

  1. Bellen HJ, Van Herbruggen C (1980) Evaluating the Quality of Life in Belgium. Social Indicators Research Aug.:311-326.
  2. Bellen HJ, van de Weghe A, Bouquet Y, van Zutphen LFM (1984) Heterogeneity of the Es-1 esterases in the rabbit (Oryctolagus cuniculus). Biochemical Genetics 22:853-870.
  3. Bellen HJ, Kiger JA Jr (1987) Sexual hyperactivity and reduced longevity of dunce females of Drosophila melanogaster. Genetics 115:153-160.
  4. Bellen HJ, Gregory BK, Olsson CL, Kiger JA Jr (1987) Two Drosophila learning mutants, dunce and rutabaga, provide evidence of a maternal role for cAMP on embryogenesis. Developmental Biology 121:432-444.
  5. Bellen HJ, Kiger JA Jr (1988) Maternal effects of general and regional specificity on embryos of Drosophila melanogaster caused by dunce and rutabaga mutant combinations. Wilhelm Roux’s Archives Developmental Biology 197:258-268.
  6. Bellen HJ, O’Kane CJ, Wilson C, Grossniklaus U, Pearson RK, Gehring WJ (1989) P-element-mediated enhancer detection: a versatile method to study development in Drosophila. Genes and Development 3:1288-1300.
  7. Wilson C, Pearson RK, Bellen HJ, O’Kane CJ, Grossniklaus U, Gehring WJ (1989) P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. Genes and Development 3:1301-1313.
  8. Grossniklaus U, Bellen HJ, Wilson C, Gehring WJ (1989) P-element mediated enhancer detection applied to the study of oogenesis in Drosophila. Development 107:189-200.
  9. Weigel D, Bellen HJ, Jürgens G, Jäckle H (1989) Primordium specific requirement of the homeotic gene fork head in the developing gut of the Drosophila embryo. Wilhelm Roux’s Archives Developmental Biology 198:201-210.
  10. Bellen HJ, Wilson C, Gibson G, Grossniklaus U, Pearson RK, O’Kane C, Gehring WJ (1990) P-element-mediated enhancer detection allows rapid identification of developmentally regulated genes and cell specific markers in Drosophila. Journal of Physiology (Paris) 84:33-41.
  11. Wilson C, Bellen HJ, Gehring WJ (1990) Position effects on eukaryotic gene expression. Annual Review of Cell Biology 6:679-714.
  12. Bellen HJ, Wilson C, Gehring WJ (1990) Dissecting the complexity of the nervous system by enhancer detection. BioEssays 12:199-204.
  13. Bellen HJ, D’Evelyn D, Harvey M, Elledge SJ (1992) Isolation of temperature-sensitive diphtheria toxins in yeast and their effects on Drosophila cells. Development 114:787-796.
  14. Bellen HJ, Vaessin H, Bier E, Kolodkin A, D’Evelyn D, Kooyer S, Jan Y-N (1992) The Drosophila couch potato gene: an essential gene required for normal adult behavior. Genetics 131:365-375.
  15. Whitehouse-Hills S, Bellen HJ, Kiger JA Jr (1992) Embryonic cAMP and developmental potential in Drosophila melanogaster. Wilhelm Roux’s Archives Developmental Biology 201:257-264.
  16. Bellen HJ, Kooyer S, D’Evelyn D, Pearlman J (1992) The Drosophila Couch potato protein is expressed in nuclei of peripheral neuronal precursors and shows homology to RNA-binding proteins. Genes and Development 6:2125-2136.
  17. Littleton JT, Bellen HJ, Perin MS (1993) Expression of synaptotagmin in Drosophila embryos reveals transport and localization of synaptic vesicles to the synapse. Development 118:1077-1088.
  18. Littleton JT, Stern M, Schulze K, Perin M, Bellen HJ (1993) Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca2+-activated neurotransmitter release. Cell 74:1125-1134.
  19. Kania A, Han P-L, Kim Y-T, Bellen HJ (1993) neuromusculin, a Drosophila gene expressed in peripheral neuronal precursors and muscles, encodes a cell adhesion molecule. Neuron 11:673-687.
  20. Eldon E, Kooyer S, D’Evelyn D, Duman M, Lawinger P, Botas J, Bellen HJ (1994) The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll. Development 120:885-899.
  21. Salzberg A, D’Evelyn D, Schulze KL, Lee J-K, Strumpf D, Tsai L, Bellen HJ (1994) Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13:269-287.
  22. Littleton JT, Bellen HJ (1994) Genetic and phenotypic analysis of thirteen essential genes in cytological interval 22F1-2; 23B1-2 reveals novel genes required for neural development in Drosophila. Genetics 138:111-123.
  23. Broadie K, Bellen HJ, DiAntonio A, Littleton JT, Schwarz TL (1994) Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission. Proceedings of the National Academy of Sciences USA 91:10727-10731.
  24. Schulze KL, Littleton JT, Salzberg A, Halachmi N, Stern M, Lev Z, Bellen HJ (1994) rop, a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo. Neuron 13:1099-1108.
  25. Littleton JT, Stern M, Perin M, Bellen HJ (1994) Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants. Proceedings of the National Academy of Sciences USA 91:10888-10892.
  26. Littleton JT, Bellen HJ (1995) Presynaptic proteins involved in exocytosis in Drosophila melanogaster: a genetic analysis. Invertebrate Neuroscience 1:3-13.
  27. Schulze KL, Broadie K, Perin MS, Bellen HJ (1995) Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission. Cell 80:311-320.
  28. Littleton JT, Bellen HJ (1995) Synaptotagmin controls and modulates synaptic-vesicle fusion in a Ca2+-dependent manner. Trends in Neuroscience 18:177-183.
  29. Kania A, Bellen HJ (1995) Mutations in neuromusculin, a gene encoding a cell adhesion molecule, cause nervous system defects. Wilhelm Roux’s Archives Developmental Biology 204:259-270.
  30. Kania A, Salzberg A, Bhat M, D’Evelyn D, He Y, Kiss I, Bellen HJ (1995) P-element mutations affecting embryonic peripheral nervous system development in Drosophila melanogaster. Genetics 139:1663-1678.
  31. Broadie K, Prokop A, Bellen HJ, O’Kane CJ, Schulze KL, Sweeney ST (1995) Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila. Neuron 15:663-673.
  32. Bellen HJ, Smith RF (1995) FlyBase: a virtual Drosophila cornucopia. Trends in Genetics 11:456-457.
  33. Salzberg A, Bellen HJ (1996) Invertebrate versus vertebrate neurogenesis: variations on the same theme? Developmental Genetics 18:1-10.
  34. Rodriguez A, Zhou Z, Tang ML, Meller S, Chen J, Bellen HJ, Kimbrell DA (1996) Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster. Genetics 143:929-940.
  35. Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ, Zoghbi HY (1996) Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. Human Molecular Genetics 5:1207-1216.
  36. Salzberg A, Golden K, Bodmer R, Bellen HJ (1996) gutfeeling, a Drosophila gene encoding an antizyme-like protein, is required for late differentiation of neurons and muscles. Genetics 144:183-196.
  37. Schulze KL, Bellen HJ (1996) Drosophila syntaxin is required for cell viability and may function in membrane formation and stabilization. Genetics 144:1713-1724.
  38. Baumgartner S, Littleton JT, Broadie K, Bhat MA, Harbecke R, Lengyel JA, Chiquet-Ehrismann R, Prokop A, Bellen HJ (1996) A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. Cell 87:1059-1068.
  39. Bhat MA, Philp AV, Glover DM, Bellen HJ (1996) Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II. Cell 87:1103-1114.
  40. Littleton JT, Bhat MA, Bellen HJ (1997) Deciphering the function of neurexins at cellular junctions. Journal of Cell Biology 137:793-796.
  41. Wu MN, Bellen HJ (1997) Genetic dissection of synaptic transmission in Drosophila. Current Opinion in Neurobiology 7:624-630.
  42. Ben-Arie N, Bellen HJ, Armstrong DL, McCall AE, Gordadze PR, Guo Q, Matzuk MM, Zoghbi HY (1997) Math1 is essential for genesis of cerebellar granule neurons. Nature 390: 169-172.
  43. Cabello OA, Baldini A, Bhat M, Bellen HJ, Belmont JW (1997) Localization of BRRN1, the human homologue of Drosophila barr, to 2q11.2. Genomics 46:311-313.
  44. Salzberg A, Prokopenko SN, He Y, Tsai P, Pál M, Maróy P, Glover DM, Deák P, Bellen HJ (1997) P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: mutations affecting embryonic PNS development. Genetics 147:1723-1741.
  45. Wu MN, Littleton JT, Bhat MA, Prokop A, Bellen HJ (1998) ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner. EMBO Journal 17:127-139.
  46. Dye CA, Lee J-K, Atkinson RC, Brewster R, Han P-L, Bellen HJ (1998) The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein. Development 125:1845-1856.
  47. Adams RR, Tavares AAM, Salzberg A, Bellen HJ, Glover DM (1998) pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis. Genes and Development 12:1483-1494.
  48. Bellen HJ (1998) The fruit fly: a model organism to study the genetics of alcohol abuse and addiction? Cell 93:909-912.
  49. Bellen HJ, Lu Y, Beckstead R, Bhat MA (1998) Neurexin IV, caspr and paranodin--novel members of the neurexin family: encounters of axons and glia. Trends in Neuroscience 21:444-449.
  50. Zhang B, Koh YH, Beckstead RB, Budnik V, Ganetzky B, Bellen HJ (1998) Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis. Neuron 21:1465-1475.
  51. Hassan BA, Prokopenko SN, Breuer S, Zhang B, Paululat A, Bellen HJ (1998) skittles, a Drosophila phosphatidylinositol 4-phosphate 5-kinase, is required for cell viability, germline development and bristle morphology, but not for neurotransmitter release. Genetics 150:1527-1537.
  52. Bhat MA, Izadoost S, Lu Y, Cho K-O, Choi K-W, Bellen HJ (1999) Discs lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Cell 96:833-845. (Erratum: Cell 115:765-766.)
  53. Bermingham NA, Hassan BA, Price SD, Vollrath MA, Ben-Arie N, Eatock RA, Bellen HJ, Lysakowski A, Zoghbi HY (1999) Math1: an essential gene for the generation of inner ear hair cells. Science 284:1837-1841.
  54. Wu MN, Fergestad T, Lloyd TE, He Y, Broadie K, Bellen HJ (1999) Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo. Neuron 23: 593-605. (Erratum: Neuron 25:735.)
  55. Zhang B, Ganetzky B, Bellen HJ, Murthy VM (1999) Tailoring uniform coats for synaptic vesicles during endocytosis. Neuron 23:419-422.
  56. Prokopenko SN, Brumby A, O’Keefe L, Prior L, He Y, Saint R, Bellen HJ (1999) A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes and Development 13:2301-2314.
  57. Bellen HJ (1999) Ten years of enhancer detection: lessons from the fly. Plant Cell 11:2271-2281.
  58. Prokopenko SN, Saint R, Bellen HJ (2000) Tissue distribution of PEBBLE RNA and Pebble protein during Drosophila embryonic development. Mechanisms of Development 90:269-273.
  59. Mao Y, Nickitenko A, Duan X, Lloyd TE, Wu MN, Bellen HJ, Quiocho FA (2000) Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction. Cell 100:447-456.
  60. Hassan BA, Bermingham NA, He Y, Sun Y, Jan Y-N, Zoghbi HY, Bellen HJ (2000) atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain. Neuron 25:549-561.
  61. Ben-Arie N, Hassan BA, Bermingham NA, Malicki DM, Armstrong D, Matzuk M, Bellen HJ, Zoghbi HY (2000) Functional conservation of atonal and Math1 in the CNS and PNS. Development 127:1039-1048.
  62. Prokopenko SN, Saint R, Bellen HJ (2000) Untying the Gordian knot of cytokinesis. Role of small G proteins and their regulators. Journal of Cell Biology 148:843-848.
  63. Lloyd TE, Verstreken P, Ostrin EJ, Phillipi A, Lichtarge O, Bellen HJ (2000) A genome-wide search for synaptic vesicle cycle proteins in Drosophila. Neuron 26:45-50.
  64. Hassan BA, Bellen HJ (2000) Doing the MATH: is the mouse a good model for fly development? Genes and Development 14:1852-1865.
  65. Nolo R, Abbott LA, Bellen HJ (2000) Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell 102:349-362.
  66. Prokopenko SN, He Y, Lu Y, Bellen HJ (2000) Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics 156:1691-1715.
  67. Nolo R, Abbott LA, Bellen HJ (2001) Drosophila Lyra mutations are gain-of-function mutations of senseless. Genetics 157:307-315.
  68. Wu MN, Schulze KL, Lloyd TE, Bellen HJ (2001) The ROP-syntaxin interaction inhibits neurotransmitter release. European Journal of Cell Biology 80:196-199.
  69. Steffenson S, Coelho PA, Cobbe N, Vass S, Costa M, Hassan B, Prokopenko SN, Bellen HJ, Heck MMS, Sunkel CE (2001) A role for Drosophila SMC4 in the resolution of sister chromatids in mitosis. Current Biology 11:295-307.
  70. Beckstead R, Ortiz JA, Sanchez C, Prokopenko SN, Chambon P, Losson R, Bellen HJ (2001) Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit βFTZ-F1-dependent transcription. Molecular Cell 7:753-765.
  71. Bhat MA, Rios JC, Lu Y, Garcia-Fresco GP, Ching W, St. Martin M, Li J, Einheber S, Chesler M, Rosenbluth J, Salzer JL, Bellen HJ (2001) Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron 30:369-383.
  72. Bermingham NA, Hassan BA, Wang VY, Fernandez M, Banfi S, Bellen HJ, Fritzsch B, Zoghbi HY (2001) Proprioceptor pathway development is dependent on MATH1. Neuron 30:411-422.
  73. Verstreken P, Bellen HJ (2001) The meaning of a mini. Science 293:443-444.
  74. Lloyd TE, Bellen HJ (2001) pRIMing synaptic vesicles for fusion. Nature Neuroscience 4:965-966.
  75. Frankfort BJ, Nolo R, Zhang Z, Bellen HJ, Mardon G (2001) senseless repression of rough is required for R8 photoreceptor differentiation in the developing Drosophila eye. Neuron 32:403-414.
  76. Fergestad T, Wu MN, Schulze KL, Lloyd TE, Bellen HJ, Broadie K (2001) Targeted mutations in the Syntaxin H3 domain specifically disrupt SNARE complex function in synaptic transmission. Journal of Neuroscience 21:9142-9150.
  77. Peter A, Schöttler P, Werner M, Beinert N, Dowe G, Burkert P, Mourkioti F, Denzer L, He Y, Deak P, Benos PV, Gatt MK, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demaille J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert S, Borkova D, Miñana B, Kafatos FC, Bolshakov S, Sidén-Kiamos I, Papagiannakis G, Spanos L, Louis C, Madueño E, de Pablos B, Modolell J, Bucheton A, Callister D, Campbell L, Henderson NS, McMillan PJ, Salles C, Tait E, Valenti P, Saunders RDC, Billaud A, Pachter L, Klapper R, Janning W, Glover DM, Ashburner M, Bellen HJ, Jäckle H, Schäfer U (2002) Mapping and identification of essential gene functions on the X chromosome of Drosophila. EMBO Reports 3: 34-38.
  78. Chen S, Zheng X, Schulze KL, Morris T, Bellen HJ, Stanley EF (2002) Enhancement of presynaptic calcium current by cysteine string protein. Journal of Physiology 538:383-389.
  79. Lloyd TE, Atkinson R, Wu MN, Zhou Y, Pennetta G, Bellen HJ (2002) Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell 108:261-269.
  80. Izaddoost S, Nam SC, Bhat MA, Bellen HJ, Choi K-W (2002) Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres. Nature 416:178-183.
  81. Verstreken P, Kjaerulff O, Lloyd TE, Atkinson R, Zhou Y, Meinertzhagen IA, Bellen HJ (2002) endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release. Cell 109:101-112.
  82. Seto E, Bellen HJ, Lloyd TE (2002) When cell biology meets development: endocytic regulation of signaling pathways. Genes and Development 16:1314-1336.
  83. Pennetta G, Hiesinger PR, Fabian-Fine R, Meinertzhagen IA, Bellen HJ (2002) Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner. Neuron 35:291-306.
  84. Verstreken P, Bellen HJ (2002) Meaningless minis? Mechanisms of neurotransmitter-receptor clustering. Trends in Neuroscience 25:383-385.
  85. Jafar-Nejad H, Norga KK, Bellen HJ (2002) Numb: "Adapting" Notch for endocytosis. Developmental Cell 3:155-156.
  86. Wang VY, Hassan BA, Bellen HJ, Zoghbi HY (2002) Drosophila atonal fully rescues the phenotype of Math1 null mice: new functions evolve in new cellular contexts. Current Biology 12:1611-1616.
  87. Kjaerulff O, Verstreken P, Bellen HJ (2002) Synaptic vesicle retrieval: still time for a kiss. Nature Cell Biology 4:E245-E248.
  88. Kango-Singh M, Nolo R, Tao C, Verstreken P, Hiesinger PR, Bellen HJ, Halder G (2002) shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 129:5719-5730.
  89. Wallis D, Hamblen M, Zhou Y, Venken KJT, Schumacher A, Grimes HL, Zoghbi HY, Orkin SH, Bellen HJ (2003) The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development 130:221-232.
  90. Koh T-W, Bellen HJ (2003) Synaptotagmin I, a Ca2+ sensor for neurotransmitter release. Trends in Neuroscience 26:413-422.
  91. Norga KK, Gurganus MC, Dilda CL, Yamamoto A, Lyman RF, Patel PH, Rubin GM, Hoskins RA, Mackay TF, Bellen HJ (2003) Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development. Current Biology 13:1388-1397.
  92. Zhai RG, Hiesinger PR, Koh T-W, Verstreken P, Schulze KL, Cao Y, Jafar-Nejad H, Norga KK, Pan H, Bayat V, Greenbaum MP, Bellen HJ (2003) Mapping Drosophila mutations with molecularly defined P element insertions. Proceedings of the National Academy of Sciences USA 100:10860-10865.
  93. Verstreken P, Koh T-W, Schulze KL, Zhai RG, Hiesinger PR, Zhou Y, Mehta SQ, Cao Y, Roos J, Bellen HJ (2003) Synaptojanin is recruited by Endophilin to promote synaptic vesicle uncoating. Neuron 40:733-748.
  94. Fabian-Fine R, Verstreken P, Hiesinger PR, Horne JA, Kostyleva R, Zhou Y, Bellen HJ, Meinertzhagen IA (2003) Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals. Journal of Neuroscience 23:10732-10744.
  95. Jafar-Nejad H, Acar M, Nolo R, Hacin H, Pan H, Parkhurst SM, Bellen HJ (2003) Senseless acts as a binary switch during sensory organ precursor selection. Genes and Development 17:2966-2978.
  96. Seto E, Bellen HJ (2004) The ins and outs of Wingless signaling. Trends in Cell Biology 14:45-53.
  97. Hiesinger PR, Bellen HJ (2004) Flying in the face of total disruption. Nature Genetics 36:211-212.
  98. Pesah Y, Pham T, Burgess H, Middlebrooks B, Verstreken P, Zhou Y, Harding M, Bellen HJ, Mardon G (2004) Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development 131:2183-2194.
  99. Bellen HJ, Levis RW, Liao G, He Y, Carlson JW, Tsang G, Evans-Holm M, Hiesinger PR, Schulze KL, Rubin GM, Hoskins RA, Spradling AC (2004) The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics 167:761-781.
  100. Koh T-W, Verstreken P, Bellen HJ (2004) The Drosophila Dap160 protein is required for endocytosis and acts as a multifunctional temperature sensitive adaptor for numerous endocytic proteins. Neuron 43:193-205.
  101. Zhai RG, Bellen HJ (2004) The architecture of the active zone in the presynaptic nerve terminal. Physiology 19:262-270.
  102. Jafar-Nejad H, Bellen HJ (2004) Gfi/Pag-3/Senseless zinc finger proteins: a unifying theme? Molecular and Cellular Biology, 24:8803-8812.
  103. Zhai RG, Bellen HJ (2004) Hauling t-SNARES on the microtubule highway. Nature Cell Biology, 6:918-919
  104. Kazanjian A, Wallis-Schultz D, Au N, Nigam R, Venken KJT, Cagle PT, Dickey BF, Bellen HJ, Gilks CB, Grimes HL (2004) Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells. Cancer Research, 64:6874-6882.
  105. Beckstead RB, Ner SS, Hales KG, Grigliatti TA, Baker BS, Bellen HJ (2005) Bonus, a Drosophila TIF1 homologue, is a chromatin associated protein that acts as a modifier of position effect variegation. Genetics 169:783-794.
  106. Escudero LM, Caminero E, Schulze KL, Bellen HJ, Modolell J. (2005) Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila. Development 132:1211-1222.
  107. Venken KJT, Bellen HJ (2005) Emerging technologies for gene manipulation in Drosophila melanogaster. Nature Reviews Genetics 6:167-178.
  108. Mehta SQ, Hiesinger PR, Beronja S, Zhai RG, Schulze KL, Verstreken P, Cao Y, Zhou Y, Tepass U, Crair MC, Bellen HJ (2005) Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron 46:219-232.
  109. Hiesinger PR, Fayyazuddin A, Mehta SQ, Rosenmund T, Schulze KL, Zhai RG, Verstreken P, Cao Y, Zhou Y, Kunz J, Bellen HJ (2005) The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell 121:607-620.
  110. Dermaut B, Norga KK, Kania A, Verstreken P, Pan H, Zhou Y, Callaerts P, Bellen HJ (2005) Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer. Journal of Cell Biology 170:127-139.
  111. Verstreken P, Ly CV, Venken KJ, Koh TW, Zhou Y, Bellen HJ (2005) Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron 47:365-378.
  112. Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJ, Botas J, Orr HT, Bellen HJ, Zoghbi HY (2005) The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell 122:633-644.
  113. Jafar-Nejad H, Andrews HK, Acar M, Bayat V, Wirtz-Peitz F, Mehta SQ, Knoblich JA, Bellen HJ (2005) Sec15, a component of the exocyst, promotes Notch signaling during the asymmetric division of Drosophila sensory organ precursors. Developmental Cell 9:351-363.
  114. Wu S, Mehta SQ, Pichaud F, Bellen HJ, Quiocho FA (2005) Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo. Nature Structural and Molecular Biology 12:879-885.
  115. Shroyer NF, Wallis D, Venken KJT, Bellen HJ, Zoghbi HY (2005) Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes and Development 19:2412-2417.
  116. Giagtzoglou N, Bellen HJ (2006) Fighting anthrax with flies. Proceedings of the National Academy of Sciences USA 103:3013-3014.
  117. Fayyazuddin A, Zaheer MA, Hiesinger PR, Bellen HJ (2006) The nicotinic acetylcholine receptor Dα7 is required for an escape behavior in Drosophila. PLoS Biology 4:e63.
  118. Seto ES, Bellen HJ (2006) Internalization is required for proper wingless signaling in Drosophila. Journal of Cell Biology 173:95-106.
  119. Jafar-Nejad H, Tien AC, Acar M, Bellen HJ (2006) Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development 133:1683-1692.
  120. Acar M, Jafar-Nejad H, Giagtzoglou N, Yallampalli S, David G, He Y, Delidakis C, Bellen HJ (2006) Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. Development 133:1979-1989.
  121. Hiesinger PR, Zhai RG, Zhou Y, Koh TW, Mehta SQ, Schulze KL, Cao Y, Verstreken P, Clandinin TR, Fischbach KF, Meinertzhagen IA, Bellen HJ (2006) Activity-independent prespecification of synaptic partners in the visual map of Drosophila. Current Biology 16:1835-1843.
  122. Zhai RG, Cao Y, Hiesinger PR, Zhou Y, Mehta SQ, Schulze KL, Verstreken P, Bellen HJ (2006) Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. PLoS Biology 4:e416.
  123. Venken KJ, He Y, Hoskins RA, Bellen HJ (2006) P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science 314:1747-1751.
  124. Zhang J, Schulze KL, Hiesinger PR, Suyama K, Wang S, Fish M, Acar M, Hoskins RA, Bellen HJ, Scott MP (2007) Thirty-one flavors of Drosophila Rab proteins. Genetics 176:1307-1322.
  125. Koh TW, Korolchuk VI, Wairkar YP, Jiao W, Evergren E, Pan H, Zhou Y, Venken KJT, Shupliakov O, Robinson IM, O'Kane CJ, Bellen HJ (2007) Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development. Journal of Cell Biology 178:309-322.
  126. Venken KJT, Bellen HJ (2007) Transgenesis uprgrades for Drosophila melanogaster. Development 134:3571-3584.
  127. Zhang W, Wang D, Volk E, Bellen HJ, Hiesinger PR, Quiocho FA (2007) V-ATPase V0 sector subunit a1 in neurons is a target of calmodulin. Journal of Biological Chemistry 283:294-300.
  128. Ohyama T, Verstreken P, Ly CV, Rosenmund T, Rajan A, Tien AC, Haueter C, Schulze KL, Bellen HJ (2007) Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles. Journal of Cell Biology 179:1481-1496.
  129. Romero E, Cha GH, Verstreken P, Ly CV, Hughes RE, Bellen HJ, Botas J (2008) Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm. Neuron 57:27-40.
  130. Acar M, Jafar-Nejad H, Takeuchi H, Rajan A, Ibrani D, Rana NA, Pan H, Haltiwanger RS, Bellen HJ (2008) Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell 132:247-258.
  131. Zhai RG, Zhang F, Hiesinger PR, Cao Y, Haueter CM, Bellen HJ (2008) NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration. Nature 452:887-991.
  132. Ly CV, Yao CK, Verstreken P, Ohyama T, Bellen HJ (2008) straightjacket is required for the synaptic stabilization of cacophony, a voltage gated calcium channel α1 subunit. Journal of Cell Biology 181:157-170.
  133. Tsuda H, Han SM, Yang Y, Tong C, Lin YQ, Mohan K, Haueter C, Zoghbi A, Harati Y, Kwan J, Miller MA, Bellen HJ (2008) The Amyotrophic Lateral Sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell 133:963-977.
  134. Tien AC, Rajan A, Schulze KL, Ryoo HD, Acar M, Steller H, Bellen HJ (2008) Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster. Journal of Cell Biology 182:1113-1125.
  135. Tien AC, Rajan A, Bellen HJ (2009) A Notch updated. Journal of Cell Biology 184:621-629.
  136. Giagtzoglou N, Lin YQ, Haueter C, Bellen HJ (2009) Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction. Journal of Neuroscience 29:5628-5639.
  137. Andrews HK, Giagtzoglou N, Yamamoto S, Schulze KL, Bellen HJ (2009) Sequoia regulates cell fate decisions in developing adult Drosophila external sensory organs. EMBO Reports 10:636–641.
  138. Venken, KJT, Carlson JW, Schulze KL, Pan H, He Y, Spokony R, Wan KH, Koriabine M, de Jong PJ, White KP, Bellen HJ, Hoskins RA (2009) Versatile P[acman] BAC Libraries for transgenesis studies in Drosophila melanogaster. Nature Methods 6:431-434.
  139. Fotowat H, Fayyazuddin A, Bellen HJ, Gabbiani F (2009) A novel neuronal pathway for visually guided escape in Drosophila melanogaster. Journal of Neurophysiology, in press.
  140. Rajan A, Tien AC, Haueter CM, Schulze KL, Bellen HJ (2009) The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nature Cell Biology 11:815-824.
  141. Patel PH, Costa-Mattioli M, Schulze KL, Bellen HJ (2009) The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. Journal of Cell Biology 185:1181-1194.
  142. Yao CK, Lin YQ, Ly CV, Ohyama T, Haueter C, Moiseenkova-Bell VY, Wensel TG, Bellen HJ (2009) A synaptic vesicle- and presynaptic membrane-associated ion channel regulates resting Ca2+ levels and synaptic endocytosis. Cell, in press.
  143. Verstreken P, Ohyama T, Haueter C, Habets RLP, Lin YQ, Swan LE, Ly CV, Venken KJT, De Camilli P, Bellen HJ (2009) Tweek, an evolutionary conserved protein, is required for synaptic vesicle recycling. Neuron, in press.

Books, Courses, Book Chapters, Book Reviews

  1. Bellen HJ (1979) (Published Thesis) Het sociaal welzijn in België (Social Welfare in Belgium). Editor: National Fund of Scientific Research: University of Antwerp (R.U.C.A.), Antwerp, Belgium, 221p.
  2. Bellen HJ (1980) (Course) Cursus Genetica met Woordenlijst (Genetics: A textbook). Editors: Bellen H.J. and J. Leroy: Student Publication Service of the University of Antwerp (R.U.C.A.), Antwerp, Belgium, 208p.
  3. Bellen HJ, Salzberg A (1996) (Editor Journal Issue) Focus on Neurogenesis. Developmental Genetics 18 (1), Wiley-Liss, New York, 91p.
  4. Bellen HJ (1999) (Editor Book) Neurotransmitter release. Oxford University Press, New York, 437p. Reviewed in Cell (2000) 101:21-23.
  5. Pennetta G, Wu MN, Bellen HJ (1999) (Book Chapter) Dissecting the molecular mechanisms of neurotransmitter release in Drosophila. In: Neurotransmitter release. Oxford University Press, New York, pp. 304-351.
  6. Lloyd TE, Bellen HJ (1999) (Book Chapter) Genetic analysis of neurotransmitter release in mice and humans. In: Neurotransmitter release. Oxford University Press, New York, pp. 352-388.
  7. Bellen HJ (2000) (Book Review) The fruitfly neuromuscular junction flexes its muscle. Cell 101: 141-143.
  8. Bellen HJ, Budnik V (2000) (Book Chapter) The Neuromuscular Junction. In: Drosophila protocols. Editors: W. Sullivan, M. Ashburner and R.S. Hawley. Cold Spring Harbor Laboratory Press, New York.
  9. Bellen HJ, Schulze KL (2004) (Book Chapter) Invertebrate Glia. In Myelin Biology and Disorders. Editor: R. Lazzarini. Elsevier Academic Press, London, 1:199-222.
  10. Verstreken P, Ohyama T, Bellen HJ (2008) (Book Chapter) FM 1-43 labelling of synaptic vesicle pools at the Drosophila neuromuscular junction. In Methods in molecular biology vol. 440: Exocytosis and endocytosis. Editor: A. Ivanov. Humana Press, Totowa, NJ, pp. 349-369.
  11. Giagtzoglou N, Ly CV, Bellen HJ (2009) (Book Chapter) Cell adhesion, the backbone of the synapse: "Vertebrate" and "Invertebrate" perspectives. In CSHL Monograph on Cell-Cell Junctions.

toptop

Invited Seminars/Symposia since 1999

toptop

Teaching Related Activities at Baylor College of Medicine (BCM)

• Courses Taught and/or Coordinated

• Curriculum Development Work

• Postdoctoral Trainees / Research Associates

• Graduate Students

 – As Major Advisor:
 – As Thesis Committee Member:

toptop


Home Introduction People Publications
Bellen Lab Home | BCM Public Site | BCM Intranet | Privacy Notices

© 2004-2007 Baylor College of Medicine
Bellen Lab
Contact Us
phone: (713) 798-8840 fax: (713) 798-3694
Houston, Texas 77030

modified 01-Jul-2009