Hector Sandoval

Contact Information

Research Interests

I am interested in the role of mitochondrial dynamics in neurons under homeostasis and neurodegeneration. Mitochondria are dynamic organelles that continually undergo fusion, fission, and trafficking. These fundamental cell biological processes control mitochondrial shape, number, size, distribution, and physiology. In particular, neurons utilize mitochondrial dynamics to provide the high demand for energy at the synaptic terminals. In order to find novel genes that regulate mitochondrial physiology/dynamics we are performing a large-scale forward genetic screen.

Publications

Chen M, Sandoval H, Wang J (2008) Selective mitochondrial autophagy during erythroid maturation. Autophagy 4:926-928.

Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J (2008) Essential role for Nix in autophagic maturation of erythroid cells. Nature 454:232-235.

Lu CP, Sandoval H, Brandt VL, Rice PA, Roth DB (2006) Amino acid residues in Rag1 crucial for DNA hairpin formation. Nature Structural and Molecular Biology 13:1010-1015.

Chen M, Wang YH, Wang Y, Huang L, Sandoval H Liu YJ, Wang J (2006) Dendritic cell apoptosis in the maintenance of immune tolerance Science 311:1160-1164.